ArticleClinical epigenetics2024
DNA methylation and whole-genome transcription analysis in CD4
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Article in Clinical epigenetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8citing papers in PubMed
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Who cites it
8 citing papers in PubMed.
- Review
- Genetic and epigenetic determinants of relapse risk in lupus nephritis.Lupus science & medicine · 2026Article
- Review
- The microbiota-systemic lupus erythematosus axis: mechanisms, diagnostics, and therapeutic frontiers.Frontiers in immunology · 2026Review
- Systemic lupus erythematosus-accelerated atherosclerosis: mechanistic insights and clinical implications.Frontiers in immunology · 2026Review
- Integrative DNA methylome and transcriptome analysis identify potential genes on the influence of dilated cardiomyopathy-associated heart failure.Clinical epigenetics · 2025Article
- T-Follicular Helper Cells and Their Role in Autoimmune Diseases.Life (Basel, Switzerland) · 2025Review
- An updated review on abnormal epigenetic modifications in the pathogenesis of systemic lupus erythematosus.Frontiers in immunology · 2024Review
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Authors and funding
30 authors.
Xiaomin Liu *Department of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Siyu Zhou *Hunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Mengjie Huang *Department of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Ming ZhaoHunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Weiguang ZhangDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Qun LiuDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Kangkang SongDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Xu WangDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Jiaona LiuDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Qing OuYangDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Zheyi DongDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Ming YangHunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China.
Zhenzhen LiDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Li LinDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Yi LiuDepartment of Blood Transfusion, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Yang YuDepartment of Blood Transfusion, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Simin LiaoDepartment of Rheumatology and Immunology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Jian ZhuDepartment of Rheumatology and Immunology, The First Medical Center, Chinese PLA General Hospital, Beijing, China.
Lin LiuDepartment of Nephrology, China-Japan Friendship Hospital, Beijing, China.
Wenge LiDepartment of Nephrology, China-Japan Friendship Hospital, Beijing, China.
Linpei JiaDepartment of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Aihua ZhangDepartment of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Chaomin GuoLaboratory Medicine Department, First Medical Center of Chinese PLA General Hospital, Beijing, China.
LiuYang YangDepartment of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Qing Gang LiDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Xueyuan BaiDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Ping LiDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China.
Guangyan CaiDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China. caiguangyan@sina.com.
Qianjin LuHunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha, China. qianlu5860@pumcderm.cams.cn.
Xiangmei ChenDepartment of Nephrology, The First Medical Center, Chinese PLA General Hospital, Chinese PLA Institute of Nephrology, State Key Laboratory of Kidney Diseases, National Clinical Research Center for Kidney Diseases, General Hospital of People's Liberation Army (301 Hospital), Haihe Laboratory of Cell Ecosystem, 28 Fuxing Road Beijing (wukesong), Beijing, 100853, China. xmchen301@126.com.
Funding
Haihe Laboratory of Cell Ecosystem Innovation Fund HHKYZX0003National Natural Science Foundation of China No. 81830019the Young Elite Scientists Sponsorship Program by CAST 2022QNRC001
Abstract
backgroundLupus nephritis (LN) is the most common cause of kidney injury in systemic lupus erythematosus (SLE) patients and is associated with increased mortality. DNA methylation, one of the most important epigenetic modifications, has been reported as a key player in the pathogenesis of SLE. Hence, our article aimed to explore DNA methylation in CD4
methodsOur study enrolled 46 SLE patients with or without kidney injury and 23 healthy controls from 2019 to 2022. CD4
resultsWe identified 243 hypomethylated sites and 778 hypermethylated sites only in the LN cohort. Three of these DMPs, cg08332381, cg03297029, and cg16797344, were validated by Bisulfite PCR and could be potential biomarkers for LN. Integrated analysis revealed that the expression of BCL2L14 and IFI27 was regulated by DNA methylation, which was validated by azacytidine (5-aza) treatment. The overexpression of BCL2L14 in CD4
conclusionOur study identified novel aberrant DMPs in CD4
Indexed as
CD4-Positive T-LymphocytesDNA MethylationLupus Erythematosus, SystemicLupus NephritisAdultBiomarkersCase-Control StudiesCpG IslandsEpigenesis, GeneticFemaleHumansMaleMiddle AgedBiomarkersBCL2L14CD4+ T cellDNA methylationLN
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What Socratic holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.