Evidence mapPaperPMID 39081789Full record

ArticleFrontiers in endocrinology2024

Cardiovascular autonomic and peripheral sensory neuropathy in women with obesity.

Nóra Keller, János Zádori, Balázs Lippai, Dalma Szöllősi, Virág Márton, Károly Wellinger, Szilvia Lada, Mónika Szűcs, Adrienn Menyhárt, Péter Kempler and 4 more

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Cutoffs, sensitivity and specificity of the Ewing battery in evaluating autonomic nervous system disorders: a systematic review.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Pooled it
  2. Observational
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Nóra Keller *Central Pharmacy, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary.
János Zádori *Institute of Reproductive Medicine, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary.
Balázs LippaiDepartment of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Dalma SzöllősiInstitute of Reproductive Medicine, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary.
Virág MártonInstitute of Reproductive Medicine, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary.
Károly WellingerInstitute of Reproductive Medicine, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary.
Szilvia LadaDirectorate of Nursing Management and Professional Education, Albert Szent-Györgyi Medical Centre, University of Szeged, Szeged, Hungary.
Mónika SzűcsDepartment of Medical Physics and Informatics, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Adrienn MenyhártDepartment of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary.
Péter KemplerDepartment of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary.
István BaczkóDepartment of Pharmacology and Pharmacotherapy, Centre of Excellence for Interdisciplinary Research, Development and Innovation, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Tamás VárkonyiDepartment of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Csaba Lengyel *Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Anna Vágvölgyi *Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: A higher incidence of neural dysfunction in people with obesity has been described. We determined the prevalence of neuropathic lesions in obese women and evaluated their potential association with anthropometric and laboratory parameters. Patients and methods: In our cross-sectional study, we enrolled female patients with obesity and without diabetes before obesity treatment. Voluntary female subjects were controls with a normal body mass index (BMI). Autonomic function was assessed by Ewing's cardiovascular reflex tests, while comprehensive peripheral neuropathic assessments were conducted utilizing the Neurometer®, Tiptherm®, Monofilament®, and Rydel-Seiffer tuning fork tests. Sudomotor function was assessed by the Neuropad®-test. Body composition was examined using the InBody 770. Results: 71 patients (mean ± SD; age: 36.1 ± 8.3 years; BMI: 40.2 ± 8.5 kg/m Conclusion: Peripheral sensory neuronal and sudomotor function impairments were detected in female patients with obesity compared to the controls with normal BMI. Cardiovascular autonomic dysfunction was also revealed by the Valsalva-ratio in these patients, suggesting the presence of parasympathetic dysfunction. The negative correlation between BMI and the 25-hydroxy-D3/D2-vitamin highlights the potential deficiency of vitamin D in the population affected by obesity.

Indexed as

ObesityPeripheral Nervous System DiseasesAdultAutonomic Nervous SystemAutonomic Nervous System DiseasesBlood PressureBody Mass IndexCardiovascular SystemCase-Control StudiesCross-Sectional StudiesFemaleHeart RateHumansMiddle AgedYoung AdultBMIbody compositioncardiovascular autonomic neuropathyobesityperipheral sensory neuropathy

Identifiers

PMID39081789
PMCPMC11286427

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.