Evidence map›Paper›PMID 39082355›Full record

ArticleFrontiers in bioscience (Landmark edition)2024

Neuronal CBP-1 is Required for Enhanced Body Muscle Proteostasis in Response to Reduced Translation Downstream of mTOR.

Santina Snow, Dilawar Ahmad Mir, Zhengxin Ma, Jordan Horrocks, Matthew Cox, Marissa Ruzga, Hussein Sayed, Aric N Rogers

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioscience (Landmark edition), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Santina SnowDepartment of Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, WI 53705, USA.
Dilawar Ahmad MirDavis Center for Regenerative Biology and Medicine, Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA.
Zhengxin MaDavis Center for Regenerative Biology and Medicine, Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA.
Jordan HorrocksDavis Center for Regenerative Biology and Medicine, Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA.
Matthew CoxDavis Center for Regenerative Biology and Medicine, Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA.
Marissa RuzgaDavis Center for Regenerative Biology and Medicine, Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA.
Hussein SayedDavis Center for Regenerative Biology and Medicine, Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA.
Aric N RogersDavis Center for Regenerative Biology and Medicine, Mount Desert Island Biological Laboratory, Salisbury Cove, ME 04672, USA.

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI JAMES A COFFMAN · 2012 to 2026
$60.0M
Understanding the role of thyroid hormone signaling during axolotl limb regenerationP20GM104318 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A. · 2013 to 2023
$23.0M
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
The MDIBL Center for Comparative Biology of Tissue Repair, Regeneration and AgingP30GM154610 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI IAIN A. DRUMMOND · 2024 to 2026
$5.0M
Translational regulation downstream of nutrient sensing in a model of Alzheimer's-related proteotoxicityR01AG062575 · NIA · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI ROGERS, ARIC N · 2019 to 2023
$2.3M
Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health P20GM0103423Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health P20GM104318Morris Scientific Discovery FundNIA NIH HHS R01 AG062575NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20 GM104318NIGMS NIH HHS P30 GM154610NIH HHS P40 OD010440NIH HHS R01AG062575ODCDC CDC HHS P40 OD010440
6 · The paper itself

Abstract

backgroundThe ability to maintain muscle function decreases with age and loss of proteostatic function. Diet, drugs, and genetic interventions that restrict nutrients or nutrient signaling help preserve long-term muscle function and slow age-related decline. Previously, it was shown that attenuating protein synthesis downstream of the mechanistic target of rapamycin (mTOR) gradually increases expression of heat shock response (HSR) genes in a manner that correlates with increased resilience to protein unfolding stress. Here, we investigate the role of specific tissues in mediating the cytoprotective effects of low translation.

methodsThis study uses genetic tools (transgenic

resultsWe use the

conclusionsLow translation in either neurons or the germline orchestrate protective adaptation in other tissues, including body muscle.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsHeat-Shock ResponseProtein BiosynthesisProteostasisTOR Serine-Threonine KinasesAnimalsAnimals, Genetically ModifiedHistone AcetyltransferasesNeuronsRNA InterferenceTranscription FactorsCaenorhabditis elegans ProteinsCBP-1 protein, C elegansHistone AcetyltransferasesTOR Serine-Threonine KinasesTranscription FactorseIF4Ghealthspanlifespanproteostasistranslation

Identifiers

PMID39082355
PMCPMC11412575

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.