ArticleScience translational medicine2024
Super-relaxed myosins contribute to respiratory muscle hibernation in mechanically ventilated patients.
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Article in Science translational medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Respiratory muscle dysfunction in mechanical ventilation: a systematic review and meta-analysis of biological mechanisms.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Pooled it
- The effect of respiratory training on lung function in intensive care unit patients: a systematic review and meta-analysis.BMC pulmonary medicine · 2026Pooled it
- Sustaining neuromuscular activation after total knee arthroplasty preserves skeletal muscle fiber size, contractility, and innervation in older adults.Experimental gerontology · 2025Trial
- VIDD or CIADD? The ventilator remains a bona fide culprit.BMC anesthesiology · 2026Article
- The contribution of mechanical ventilation to critical illness-associated diaphragm dysfunction: longitudinal trajectories alone do not establish causal primacy.Critical care (London, England) · 2026Article
- The hallmarks of skeletal muscle health.Nature metabolism · 2026Review
- Myosin Post-Translational Modifications Associated With Critical Illness Myopathy.Acta physiologica (Oxford, England) · 2026Article
- Species-specific effects of positive end-expiratory pressure on diaphragm and chest wall geometry in mice, rats, and humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Evaluating skeletal muscle dysfunction and recovery in a zymosan model of critical illness in mice.Disease models & mechanisms · 2026Article
- The contribution of mechanical ventilation to critical illness-associated diaphragm dysfunction: a critical appraisal.Critical care (London, England) · 2026Review
- Loss of Myonuclei and Transcriptional Activity During Diaphragm Atrophy in Critically Ill Patients.Journal of cachexia, sarcopenia and muscle · 2026Article
- Destabilization of cardiac myosin acetylation and sequestration with type 2 diabetes mellitus.Cardiovascular diabetology · 2026Article
- Monitoring diaphragmatic effort during diaphragm neurostimulation-assisted ventilation.Critical care (London, England) · 2025Article
- Ultrasound innovations in diaphragm assessment: an integrative review of expanding clinical applications.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Ventilator-induced diaphragmatic dysfunction: pathophysiology, monitoring and advances in potential treatment and prevention.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- Dysregulated skeletal muscle myosin super-relaxation and energetics in male participants with type 2 diabetes mellitus.Diabetologia · 2025Article
- Assessing inspiratory drive and effort in critically ill patients at the bedside.Critical care (London, England) · 2025Review
- Evaluating skeletal muscle wasting and weakness in models of critical illness.Clinical science (London, England : 1979) · 2025Review
- In vitro and in vivo muscle mass and strength during the first week of critical illness.Intensive care medicine experimental · 2025Article
- A combined experimental and computational analysis of mantATP turnover in skinned muscle fibers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors.
Marloes van den BergAmsterdam UMC, Location VUmc, Department of Physiology, Amsterdam 1081, HV, Netherlands.ORCID 0000-0003-0920-6139
Zhonghua ShiAmsterdam UMC, Location VUmc, Department of Physiology, Amsterdam 1081, HV, Netherlands.ORCID 0000-0001-6331-0397
Wout J ClaassenAmsterdam UMC, Location VUmc, Department of Physiology, Amsterdam 1081, HV, Netherlands.ORCID 0000-0001-5154-7311
Pleuni HooijmanAmsterdam UMC, Location VUmc, Department of Physiology, Amsterdam 1081, HV, Netherlands.ORCID 0009-0000-2648-5219
Christopher T A LewisUniversity of Copenhagen, Department of Biomedical Sciences, Copenhagen 2200, Denmark.ORCID 0000-0003-4477-422X
Jesper L AndersenBispebjerg Hospital, Institute of Sports Medicine, Copenhagen 2400, Denmark.ORCID 0000-0001-8302-0071
Robbert J van der PijlDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson AZ 85721, USA.ORCID 0000-0002-9823-0589
Sylvia J P BogaardsAmsterdam UMC, Location VUmc, Department of Physiology, Amsterdam 1081, HV, Netherlands.ORCID 0000-0002-7127-3458
Stefan ConijnAmsterdam UMC, Location VUmc, Department of Physiology, Amsterdam 1081, HV, Netherlands.ORCID 0000-0002-0860-7611
Eva L PetersDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson AZ 85721, USA.ORCID 0000-0001-6846-2154
Leon P L BegthelAmsterdam UMC, Location VUmc, Department of Physiology, Amsterdam 1081, HV, Netherlands.ORCID 0000-0002-1922-8713
Bas UijterwijkAmsterdam UMC, Location VUmc, Department of Physiology, Amsterdam 1081, HV, Netherlands.ORCID 0000-0003-2479-2092
Johan LindqvistDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson AZ 85721, USA.ORCID 0000-0003-4010-013X
Paul R LanglaisDepartment of Endocrinology, University of Arizona, Tucson, AZ 85721, USA.ORCID 0000-0003-1929-737X
Armand R J GirbesAmsterdam UMC, Location VUmc, Department of Intensive Care Medicine, Amsterdam 1081, HV, Netherlands.ORCID 0000-0002-0711-0494
Sandra StapelAmsterdam UMC, Location VUmc, Department of Intensive Care Medicine, Amsterdam 1081, HV, Netherlands.
Henk GranzierDepartment of Cellular and Molecular Medicine, University of Arizona, Tucson AZ 85721, USA.ORCID 0000-0002-9516-407X
Kenneth S CampbellDivision of Cardiovascular Medicine, University of Kentucky College of Medicine, Lexington, KY 40536, USA.ORCID 0000-0001-5615-5958
Weikang MaBioCAT, Illinois Institute of Technology, Lemont, IL 60439, USA.ORCID 0000-0001-9535-7114
Thomas IrvingBioCAT, Illinois Institute of Technology, Lemont, IL 60439, USA.ORCID 0000-0003-4848-3323
Darren T HweeResearch and Early Development, Cytokinetics Inc., South San Francisco, CA 94080, USA.ORCID 0000-0002-3641-7348
James J HartmanResearch and Early Development, Cytokinetics Inc., South San Francisco, CA 94080, USA.ORCID 0000-0001-8301-0199
Fady I MalikResearch and Early Development, Cytokinetics Inc., South San Francisco, CA 94080, USA.ORCID 0000-0002-5597-5759
Marinus PaulAmsterdam UMC, Location VUmc, Department of Cardiothoracic Surgery, Amsterdam 1081, HV, Netherlands.ORCID 0000-0001-5415-5663
Albertus BeishuizenMedisch Spectrum Twente, Intensive Care Center, Enschede 7511, HN, Netherlands.ORCID 0000-0002-0564-250X
Julien OchalaUniversity of Copenhagen, Department of Biomedical Sciences, Copenhagen 2200, Denmark.ORCID 0000-0002-6358-2920
Leo HeunksRadboud UMC, Department of Intensive Care, Nijmegen 6525, GA, Netherlands.
Coen A C OttenheijmAmsterdam UMC, Location VUmc, Department of Physiology, Amsterdam 1081, HV, Netherlands.ORCID 0000-0002-8808-4813
Funding
The Biophysics Collaborative Access Team (User Training and Outreach)P30GM138395 · NIGMS · ILLINOIS INSTITUTE OF TECHNOLOGY · PI THOMAS C IRVING · 2021 to 2026
$16.5MRole of the giant protein titin in cardiac health and diseaseR35HL144998 · NHLBI · UNIVERSITY OF ARIZONA · PI GRANZIER, HENK L. · 2019 to 2025
$6.3MRole of titin in the pathophysiology of diaphragm weakness during mechanical ventilationR01HL121500 · NHLBI · UNIVERSITY OF ARIZONA · PI Coen Ottenheijm · 2014 to 2026
$6.2MComputer modeling of myosin binding protein C and its effects on cardiac contractionR01HL146676 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI Kenneth S Campbell, Julian Stelzer · 2019 to 2026
$4.3MDual filament control of myocardial power and hemodynamicsR01HL148785 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI Kenneth S Campbell, Thomas Kampourakis · 2020 to 2026
$3.2MData-driven optimization of therapy for heart failureR01HL163977 · NHLBI · UNIVERSITY OF KENTUCKY · PI CAMPBELL, KENNETH S, LEE, LIK CHUAN · 2022 to 2025
$2.4MNHLBI NIH HHS R01 HL121500NHLBI NIH HHS R01 HL146676NHLBI NIH HHS R01 HL163977NHLBI NIH HHS R35 HL144998NIGMS NIH HHS P30 GM138395
Abstract
Patients receiving mechanical ventilation in the intensive care unit (ICU) frequently develop contractile weakness of the diaphragm. Consequently, they may experience difficulty weaning from mechanical ventilation, which increases mortality and poses a high economic burden. Because of a lack of knowledge regarding the molecular changes in the diaphragm, no treatment is currently available to improve diaphragm contractility. We compared diaphragm biopsies from ventilated ICU patients (
Indexed as
DiaphragmMuscle ContractionMyosinsRespiration, ArtificialRespiratory MusclesActinsAgedAnimalsFemaleHibernationHumansIntensive Care UnitsMaleMiddle AgedRatsActinsMyosins
Identifiers
What Socratic holds
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Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.