Evidence map›Paper›PMID 39084540›Full record

ArticleBrain, behavior, and immunity2024

Elevated antibody binding to striatal cholinergic interneurons in patients with pediatric acute-onset neuropsychiatric syndrome.

Jian Xu, Jennifer Frankovich, Rong-Jian Liu, Margo Thienemann, Melissa Silverman, Bahare Farhadian, Theresa Willett, Cindy Manko, Laurie Columbo, Collin Leibold and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, and immunity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jian XuDepartments of Psychiatry, Yale University, New Haven, CT, USA. Electronic address: jian.xu@yale.edu.
Jennifer FrankovichDepartments of Pediatrics, Stanford University School of Medicine, Stanford University, CA, USA; Immune Behavioral Health Clinic and Research Program, Stanford University School of Medicine, Stanford University, CA, USA; Division of Allergy, Immunology, Rheumatology, Stanford University School of Medicine, Stanford University, CA, USA.
Rong-Jian LiuDepartments of Psychiatry, Yale University, New Haven, CT, USA.
Margo ThienemannDepartments of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, CA, USA; Immune Behavioral Health Clinic and Research Program, Stanford University School of Medicine, Stanford University, CA, USA; Division of Child & Adolescent Psychiatry and Child Development, Stanford University School of Medicine, Stanford University, CA, USA.
Melissa SilvermanDepartments of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford University, CA, USA; Immune Behavioral Health Clinic and Research Program, Stanford University School of Medicine, Stanford University, CA, USA; Division of Child & Adolescent Psychiatry and Child Development, Stanford University School of Medicine, Stanford University, CA, USA.
Bahare FarhadianImmune Behavioral Health Clinic and Research Program, Stanford University School of Medicine, Stanford University, CA, USA; Division of Allergy, Immunology, Rheumatology, Stanford University School of Medicine, Stanford University, CA, USA.
Theresa WillettDepartments of Pediatrics, Stanford University School of Medicine, Stanford University, CA, USA; Immune Behavioral Health Clinic and Research Program, Stanford University School of Medicine, Stanford University, CA, USA; Division of Allergy, Immunology, Rheumatology, Stanford University School of Medicine, Stanford University, CA, USA.
Cindy MankoDepartments of Pediatrics, Stanford University School of Medicine, Stanford University, CA, USA; Immune Behavioral Health Clinic and Research Program, Stanford University School of Medicine, Stanford University, CA, USA; Division of Allergy, Immunology, Rheumatology, Stanford University School of Medicine, Stanford University, CA, USA.
Laurie ColumboDepartments of Pediatrics, Stanford University School of Medicine, Stanford University, CA, USA; Immune Behavioral Health Clinic and Research Program, Stanford University School of Medicine, Stanford University, CA, USA; Division of Allergy, Immunology, Rheumatology, Stanford University School of Medicine, Stanford University, CA, USA.
Collin LeiboldImmune Behavioral Health Clinic and Research Program, Stanford University School of Medicine, Stanford University, CA, USA.
Flora M VaccarinoDepartments of Neuroscience, Yale University, New Haven, CT, USA; Child Study Center, Yale University, New Haven, CT, USA.
Alicia CheDepartments of Psychiatry, Yale University, New Haven, CT, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA; Wu-Tsai Institute, Yale University, New Haven, CT, USA; Center for Brain and Mind Health, Yale University, New Haven, CT, USA.
Christopher PittengerDepartments of Psychiatry, Yale University, New Haven, CT, USA; Departments of Psychology, Yale University, New Haven, CT, USA; Child Study Center, Yale University, New Haven, CT, USA; Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA; Wu-Tsai Institute, Yale University, New Haven, CT, USA; Center for Brain and Mind Health, Yale University, New Haven, CT, USA. Electronic address: christopher.pittenger@yale.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Neurodevelopment of Tourette syndromeR01MH118453 · NIMH · YALE UNIVERSITY · PI FLORA M VACCARINO · 2019 to 2026
$4.0M
Anti-interneuron antibodies in rapid-onset pediatric OCD: clinical generalization and target identificationR01MH127259 · NIMH · YALE UNIVERSITY · PI Christopher John Pittenger · 2022 to 2026
$4.0M
Histamine Regulation of the Basal Ganglia and the Pathophysiology of TicsR01NS101104 · NINDS · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN · 2017 to 2021
$2.3M
Neural Mechanisms Linking Sensory Perception and Social BehaviorR01NS133434 · NINDS · YALE UNIVERSITY · PI Alicia Yue Che · 2023 to 2026
$1.6M
Effects of Early-life Cannabinoid Exposure on Prefrontal Circuitry and Cognitive Behavior across DevelopmentR01DA059378 · NIDA · YALE UNIVERSITY · PI Alicia Yue Che · 2024 to 2026
$1.5M
Maturation of Somatosensory Circuits for Social BehaviorsR00NS114166 · NINDS · YALE UNIVERSITY · PI CHE, ALICIA YUE · 2022 to 2024
$740k
Histamine Regulation of Basal Ganglia FunctionR21MH109700 · NIMH · YALE UNIVERSITY · PI PITTENGER, CHRISTOPHER JOHN · 2016 to 2017
$404k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS R01 DA059378NIMH NIH HHS R01 MH118453NIMH NIH HHS R01 MH127259NIMH NIH HHS R21 MH109700NINDS NIH HHS R00 NS114166NINDS NIH HHS R01 NS101104NINDS NIH HHS R01 NS133434
6 · The paper itself

Abstract

Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by the abrupt onset of significant obsessive-compulsive symptoms (OCS) and/or severe food restriction, together with other neuropsychiatric manifestations. An autoimmune pathogenesis triggered by infection has been proposed for at least a subset of PANS. The older diagnosis of Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcus (PANDAS) describes rapid onset of OCD and/or tics associated with infection with Group A Streptococcus. The pathophysiology of PANS and PANDAS remains incompletely understood. We recently found serum antibodies from children with rigorously defined PANDAS to selectively bind to cholinergic interneurons (CINs) in the striatum. Here we examine this binding in children with relapsing and remitting PANS, a more heterogeneous condition, collected in a distinct clinical context from those examined in our previous work, from children with a clinical history of Streptococcus infection. IgG from PANS cases showed elevated binding to striatal CINs in both mouse and human brain. Patient plasma collected during symptom flare decreased a molecular marker of CIN activity, phospho-riboprotein S6, in ex vivo brain slices; control plasma did not. Neither elevated antibody binding to CINs nor diminished CIN activity was seen with plasma collected from the same children during remission. These findings replicate what we have seen previously in PANDAS and support the hypothesis that at least a subset of PANS cases have a neuroimmune pathogenesis. Given the critical role of CINs in modulating basal ganglia function, these findings confirm striatal CINs as a locus of interest in the pathophysiology of both PANS and PANDAS.

Indexed as

Corpus StriatumInterneuronsObsessive-Compulsive DisorderStreptococcal InfectionsAdolescentAnimalsAutoantibodiesAutoimmune DiseasesChildChild, PreschoolCholinergic NeuronsFemaleHumansImmunoglobulin GMaleMiceAutoantibodiesImmunoglobulin GAntibody bindingCholinergic interneuronsDorsal striatumNeuronal activityOCDPANDASPANSPhospho-rpS6Plasma autoantibodies

Identifiers

PMID39084540
PMCPMC11569416

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.