ArticleNature communications2024
Botrytis cinerea combines four molecular strategies to tolerate membrane-permeating plant compounds and to increase virulence.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Cell Biology of Botrytis: Live-Cell Imaging Techniques and Protein Localization Protocols.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Assessing Sensitivity to Antifungal Plant Compounds or Agrochemicals.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Optimisation of Culture Conditions Enhances Antifungal Activity and Reshapes Extracellular Metabolite Profiles inMicroorganisms · 2026Article
- The penta-EF-hand protein Pef1 of Candida albicans functions at sites of membrane perturbation to support polarized growth and membrane integrity.G3 (Bethesda, Md.) · 2026Article
- The Role of Two Glycoalkaloid Metabolism Genes in α-Tomatine Biosynthesis and Basal Defence in Tomato.Molecular plant pathology · 2026Article
- Combined generalist and host-specific transcriptional strategies enable host generalism in the fungal pathogenProceedings of the National Academy of Sciences of the United States of America · 2026Article
- A multiplant transcriptomic atlas reveals conserved and lineage-specific defense architectures in response toProceedings of the National Academy of Sciences of the United States of America · 2026Article
- CHiC gene positively regulates the resistance to Botrytis cinerea in Arabidopsis.Plant cell reports · 2026Article
- Loss of virulence ofmBio · 2026Article
- The effects and potential mechanisms of statins on growth, development and pathogenicity in Botrytis cinerea.World journal of microbiology & biotechnology · 2025Article
- The chitin synthase regulator CSR-3 promotes cellular integrity during cell-cell fusion in the filamentous ascomycete fungus Neurospora crassa.PLoS genetics · 2025Article
- Advancing forest pathology: the need for community-driven molecular experimental model systems.The New phytologist · 2025Review
- Polygenic strategies for host-specific and general virulence of Botrytis cinerea across diverse eudicot hosts.Genetics · 2025Article
- Spotibot: Rapid scoring ofPlant phenomics (Washington, D.C.) · 2025Article
- Article
- Sterol Regulatory Element-Binding Protein Sre1 Mediates the Development and Pathogenicity of the Grey Mould FungusInternational journal of molecular sciences · 2025Article
- Biochemical and genetic characterization ofFrontiers in plant science · 2025Article
- The proteomic response ofmicroLife · 2025Article
- Establishment of a Mutant Library for Infection Cushion Development and Identification of a Key Regulatory Gene inJournal of fungi (Basel, Switzerland) · 2024Article
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Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Saponins are plant secondary metabolites comprising glycosylated triterpenoids, steroids or steroidal alkaloids with a broad spectrum of toxicity to microbial pathogens and pest organisms that contribute to basal plant defense to biotic attack. Secretion of glycosyl hydrolases that enzymatically convert saponins into less toxic products was thus far the only mechanism reported to enable fungal pathogens to colonize their saponin-containing host plant(s). We studied the mechanisms that the fungus Botrytis cinerea utilizes to be tolerant to well-characterized, structurally related saponins from tomato and Digitalis purpurea. By gene expression studies, comparative genomics, enzyme assays and testing a large panel of fungal (knockout and complemented) mutants, we unraveled four distinct cellular mechanisms that participate in the mitigation of the toxic activity of these saponins and in virulence on saponin-producing host plants. The enzymatic deglycosylation that we identified is novel and unique to this fungus-saponin combination. The other three tolerance mechanisms operate in the fungal membrane and are mediated by protein families that are widely distributed in the fungal kingdom. We present a spatial and temporal model on how these mechanisms jointly confer tolerance to saponins and discuss the repercussions of these findings for other plant pathogenic fungi, as well as human pathogens.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.