Evidence map›Paper›PMID 39085247›Full record

ArticleNPJ vaccines2024

A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challenge.

Jessica J Harrison, Wilson Nguyen, Mahali S Morgan, Bing Tang, Gervais Habarugira, Henry de Malmanche, Morgan E Freney, Naphak Modhiran, Daniel Watterson, Abigail L Cox and 9 more

Abstract read
In one paragraph

Article in NPJ vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jessica J Harrison *School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, 4072, Australia.ORCID http://orcid.org/0000-0002-3577-9910
Wilson Nguyen *QIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.
Mahali S MorganSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, 4072, Australia.ORCID http://orcid.org/0000-0002-4423-1252
Bing TangQIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.
Gervais HabarugiraSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, 4072, Australia.ORCID http://orcid.org/0000-0001-5858-0421
Henry de MalmancheSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, 4072, Australia.
Morgan E FreneySchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, 4072, Australia.
Naphak ModhiranSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, 4072, Australia.
Daniel WattersonSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, 4072, Australia.ORCID http://orcid.org/0000-0001-5957-2853
Abigail L CoxQIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.ORCID http://orcid.org/0000-0001-6685-3960
Kexin YanQIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.
Nicholas K Y YuenSchool of Veterinary Science, The University of Queensland, Gatton, QLD, 4343, Australia.ORCID http://orcid.org/0000-0001-7406-8102
Dylan H BowmanSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, 4072, Australia.
Peter D KirklandDepartment of Primary Industries, Elizabeth Macarthur Agricultural Institute, Menangle, NSW, 2568, Australia.
Helle Bielefeldt-OhmannSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, 4072, Australia.ORCID http://orcid.org/0000-0002-5332-5445
Andreas SuhrbierQIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia.ORCID http://orcid.org/0000-0001-8986-9025
Roy A HallSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, 4072, Australia.ORCID http://orcid.org/0000-0001-5778-1387
Daniel J RawleQIMR Berghofer Medical Research Institute, Brisbane, 4029, Australia. daniel.rawle@qimrberghofer.edu.au.ORCID http://orcid.org/0000-0001-7248-0101
Jody Hobson-PetersSchool of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, 4072, Australia. j.peters2@uq.edu.au.ORCID http://orcid.org/0000-0003-0139-9829

Funding

Department of Health | National Health and Medical Research Council (NHMRC) APP1173880Department of Health | National Health and Medical Research Council (NHMRC) APP1178896
6 · The paper itself

Abstract

In 2022, a genotype IV (GIV) strain of Japanese encephalitis virus (JEV) caused an unprecedented and widespread outbreak of disease in pigs and humans in Australia. As no veterinary vaccines against JEV are approved in Australia and all current approved human and veterinary vaccines are derived from genotype (G) III JEV strains, we used the recently described insect-specific Binjari virus (BinJV) chimeric flavivirus vaccine technology to produce a JEV GIV vaccine candidate. Herein we describe the production of a chimeric virus displaying the structural prM and E proteins of a JEV GIV isolate obtained from a stillborn piglet (JEV

Identifiers

PMID39085247
PMCPMC11291493

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.