ArticleNature medicine2024
Cranioencephalic functional lymphoid units in glioblastoma.
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Article in Nature medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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38citing papers in PubMed, 1 pooled it
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- T cell immunity in glioma and potential implications for immunotherapy: A systematic review.Neuro-oncology · 2026Pooled it
- The glymphatic-lymphatic axis: known pathways, open questions, and emerging roles in neurodegeneration.Translational neurodegeneration · 2026Review
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- Beyond dose escalation in glioblastoma: Lessons learned from INTRAGO-II and the case for targeting tumor biology.Neuro-oncology · 2026Article
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- Spatially Distinct Bone Marrow Sites Are Asymmetrically Impacted by Inflammatory Cardiovascular Disease.JACC. Basic to translational science · 2026Article
- LRIG2 suppresses NK cell-induced GSDME-mediated pyroptosis via the LAMP1-STAT3 pathway in glioma.Journal for immunotherapy of cancer · 2026Article
- Immunotherapy for Glioma: A compartmental framework for resistance and rational combination design.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Review
- Brain barriers at the crossroads of glioma immune surveillance and immunotherapy response.Nature reviews. Cancer · 2026Review
- Virus-specific CD8 T cells rapidly populate and persist in skull bone marrow after brain infection.Research square · 2026Article
- Glioblastoma: epidemiology, molecular pathogenesis, diagnosis, management, and therapeutic resistance.Molecular biomedicine · 2026Review
- Glioblastoma Stem Cells as Targets for Emerging Precision Immunotherapies and Molecular Treatments.Cells · 2026Review
- Peripheral vaccination-induced brain-resident memory CD8+ T cells durably protect mice against intracranial malignancy.The Journal of clinical investigation · 2026Article
- Myeloid-derived immunosuppression of chimeric antigen receptor T cells in the neuronal microenvironment of glioblastoma.BMC medicine · 2026Article
- Redefining the immune microenvironment of gliomas in the era of single-cell genomics.Neuro-oncology advances · 2026Review
- Resilient Calvarial Bone Marrow Supports Retinal Repair in Type 2 Diabetes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- The cribriform plate: A dynamic central nervous system-immune hub.The Journal of experimental medicine · 2026Review
- Childhood brain tumors instruct cranial hematopoiesis and immunotolerance.Nature genetics · 2026Article
- Targeting skull bone marrow hematopoiesis for the treatment of childhood brain tumors.Nature genetics · 2026Article
- The development of CAR T cells for patients with CNS malignancies.Nature reviews. Clinical oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors.
Celia DobersalskeGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0003-4233-102X
Laurèl RauschenbachGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0001-8348-4298
Yichao HuaDepartment of Applied Computational Cancer Research, IKIM, University Hospital Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-1695-172X
Christoph BerlinerDepartment of Nuclear Medicine, University Hospital Essen, Essen, Germany.ORCID http://orcid.org/0000-0001-9201-8803
Anita SteinbachGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Anika GrüneboomLeibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.ORCID http://orcid.org/0000-0002-7928-5613
Konstantinos D KokkaliarisDr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Dieter H HeilandDKTK, German Cancer Consortium, partner site Freiburg, Translational Neurosurgery, Microenvironment and Immunology Research Laboratory, University of Freiburg, Freiburg, Germany.ORCID http://orcid.org/0000-0002-9258-3033
Pia BergerGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0003-1453-3193
Sarah LangerGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0003-0286-7233
Chin L TanCCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-2529-1030
Martin StenzelLeibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.
Somaya LandolsiDr. Senckenberg Institute of Pathology, University Hospital Frankfurt, Frankfurt am Main, Germany.
Flora WeberLeibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.ORCID http://orcid.org/0000-0001-6407-8542
Marvin Darkwah OppongDepartment of Neurosurgery and Spine Surgery, University Hospital Essen, Essen, Germany.
Rudolf A WernerDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Hanah GullGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Thomas SchröderDepartment of Hematology and Stem Cell Transplantation, University Hospital Essen, Essen, Germany.
Thomas LinsenmannDepartment of Neurosurgery, University Hospital Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0001-6763-8680
Andreas K BuckDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Matthias GunzerLeibniz-Institut für Analytische Wissenschaften-ISAS-e.V., Dortmund, Germany.ORCID http://orcid.org/0000-0002-5534-6055
Martin StuschkeGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Kathy KeyvaniInstitute of Neuropathology, University Hospital Essen, Essen, Germany.ORCID http://orcid.org/0000-0003-2558-5159
Michael ForstingDepartment of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany.
Martin GlasGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Jonathan KipnisBrain Immunology and Glia (BIG) Center, Washington University School of Medicine in St Louis, St Louis, MO, USA.ORCID http://orcid.org/0000-0002-3714-517X
Dennis A SteindlerSteindler Consulting, Boston, MA, USA.
Hans Christian ReinhardtGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Edward W GreenCCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-1922-2298
Michael PlattenCCU Neuroimmunology and Brain Tumor Immunology, German Cancer Research Center, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-4746-887X
Alpaslan TasdoganGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0003-2543-852X
Ken HerrmannGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Florian RambowGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Igor CimaGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.
Ulrich SureGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany.ORCID http://orcid.org/0000-0002-9073-1821
Björn SchefflerGerman Cancer Consortium (DKTK), partner site Essen/Düsseldorf, a partnership between DKFZ and University Hospital Essen, University Duisburg-Essen, Essen, Germany. b.scheffler@dkfz-heidelberg.de.ORCID http://orcid.org/0000-0001-8316-6556
Funding
Deutsche Forschungsgemeinschaft (German Research Foundation) 404521405; SFB1389-UNITEDeutsche Forschungsgemeinschaft (German Research Foundation) HE 8145/6-1/5-1Deutsche Forschungsgemeinschaft (German Research Foundation) RE 2246/13-1Deutsche Forschungsgemeinschaft (German Research Foundation) SCHE656/2-2, proj#405344257Deutsche Forschungsgemeinschaft (German Research Foundation) SFB1399-A01Deutsche Forschungsgemeinschaft (German Research Foundation) SFB1430-A09Deutsche Forschungsgemeinschaft (German Research Foundation) SFB1530-A01Deutsche Krebshilfe (German Cancer Aid) 1117240, 70113041Wilhelm Sander-Stiftung (Wilhelm Sander Foundation) 2019.008.2
Abstract
The ecosystem of brain tumors is considered immunosuppressed, but our current knowledge may be incomplete. Here we analyzed clinical cell and tissue specimens derived from patients presenting with glioblastoma or nonmalignant intracranial disease to report that the cranial bone (CB) marrow, in juxtaposition to treatment-naive glioblastoma tumors, harbors active lymphoid populations at the time of initial diagnosis. Clinical and anatomical imaging, single-cell molecular and immune cell profiling and quantification of tumor reactivity identified CD8
Indexed as
Brain NeoplasmsCD8-Positive T-LymphocytesGlioblastomaReceptors, CXCR4AdultAgedBone MarrowFemaleHumansMaleMiddle AgedSkullSphingosine-1-Phosphate ReceptorsCXCR4 protein, humanReceptors, CXCR4Sphingosine-1-Phosphate Receptors
Identifiers
What Socratic holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.