ArticleJournal of the American Heart Association2024
Childhood Adiposity and Risk of Major Clinical Heart Diseases in Adulthood: A Mendelian Randomization Study.
Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- How to Teach Healthy Life-Style Efficiently in a Pediatric Outpatient Setting: Proposal of an Innovative Tridimensional Pyramid.Nutrients · 2026Pooled it
- Obesity and Left Ventricular Mechanics in Children and Adolescents: A Systematic Review and Meta-Analysis.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Pooled it
- Hepatic Steatosis and Cardiovascular Risk in Obesity: A 10-Year Follow-Up Study From Childhood Into Young Adulthood.Pediatric obesity · 2026Article
- Joint Associations of Prenatal Per- and Polyfluoroalkyl Substances and Metal Mixtures with Adiposity in Childhood and Adolescence.Environmental science & technology · 2026Article
- Childhood Obesity and the Future Burden of Adult Cardiometabolic Disease: A Narrative Review.Cureus · 2026Review
- Prevalence and Associated Factors of Overweight and Obesity among School-Aged Children in Zhuzhou, China.Obesity surgery · 2026Article
- The causal role of genetically predicted obesity-related traits in heart failure: systematic review and meta-analysis of Mendelian randomization studies.Frontiers in cardiovascular medicine · 2026Review
- Effects of a "5 + 2" dietary management model on body composition and behavioral modification in Chinese children with obesity: a prospective, non-randomized controlled trial.Frontiers in nutrition · 2026Article
- Improvements in body composition and postural control in children with obesity following an AI-assisted, deficit-oriented exercise intervention.Frontiers in public health · 2026Article
- Foetal Metformin Exposure, Childhood Adiposity and Future Cardiovascular Risk: Can We Connect the Dots?TouchREVIEWS in endocrinology · 2025Review
- Does a heritable common latent factor explain body mass index, percent body fat, and waist circumference across childhood?International journal of obesity (2005) · 2025Article
- Chronic pain and incident hypertension: an observational study of 0.4 million adults.Journal of health, population, and nutrition · 2025Observational
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe causal relationship between childhood adiposity and adult risk of heart diseases has not been clearly demonstrated. This study aims to ascertain whether genetically predicted childhood body mass index (BMI) and childhood obesity are causally associated with adult coronary heart disease, myocardial infarction, heart failure, atrial fibrillation, hypertrophic cardiomyopathy, and pulmonary heart disease. METHODS AND
resultsTo investigate the causative relationships and underlying mechanisms between childhood adiposity and adult heart diseases, 3 main methods of Mendelian randomization were used: 2-sample Mendelian randomization, multivariable Mendelian randomization with controlling for several cardiometabolic risk variables, and mediation analysis. Every 1-SD rise in genetically predicted childhood body mass index was associated with 24% (odds ratio [OR], 1.24 [95% CI, 1.12-1.37]), 28% (OR, 1.28 [95% CI, 1.14-1.42]), 28% (OR, 1.28 [95% CI, 1.14-1.42]), and 27% (OR, 1.27 [95% CI, 1.04-1.49]) higher risk of coronary heart disease, myocardial infarction, heart failure, and atrial fibrillation, respectively. Every 1-unit increase in log-odds in childhood obesity was associated with 11% (OR, 1.11 [95% CI, 1.06-1.16]), 14% (OR, 1.14 [95% CI, 1.04-1.23]), 10% (OR, 1.10 [95% CI, 1.03-1.18]), and 20% (OR, 1.20 [95% CI, 1.08-1.32]) higher risk of coronary heart disease, myocardial infarction, heart failure, and atrial fibrillation, respectively. The link between childhood adiposity and adult heart diseases was found to be mediated by high-density lipoprotein cholesterol, triglyceride, hypertension, and type 2 diabetes.
conclusionsOur findings support the causal relationships between childhood adiposity and risk of adult coronary heart disease, myocardial infarction, heart failure, and atrial fibrillation. Blood lipids, hypertension, and type 2 diabetes are factors that mediate the aforementioned associations.
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