Evidence map›Paper›PMID 39085768›Full record

ArticleBMC cardiovascular disorders2024

Branched-chain amino acids and the risk of hypertension; a persian cohort-based study.

Zahra Salimi, Bahareh Aminnezhad Kavkani, Pooneh Allahyari, Seyed Ali Askarpour, Zahra Mahmoudi, Mahdie Torkaman, Mohadeseh Sadat Mousavi Hoseini, Zahra Mousavi, Shirin Tajadod, Neda Valisoltani and 4 more

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In one paragraph

Article in BMC cardiovascular disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Zahra SalimiStudent Research Committee, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Bahareh Aminnezhad KavkaniDepartment of Nutrition. Science and Research Branch, Islamic Azad University, Tehran, Iran.
Pooneh AllahyariDepartment of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
Seyed Ali AskarpourDepartment of Environmental Health Engineering, Division in Food Safety and Hygiene, Tehran University of Medical Sciences, Tehran, Iran.
Zahra MahmoudiDepartment of Nutrition, Science and Research Branch , Islamic Azad University, Tehran, Iran.
Mahdie TorkamanDepartment of Chemical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Mohadeseh Sadat Mousavi HoseiniDepartment of Food Science and Technology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
Zahra MousaviNursing and Midwifery school, Shahed University, Tehran, Iran.
Shirin TajadodDepartment of Nutrition, School of Public Health, International Campus, Iran University of Medical Sciences, Tehran, Iran.
Neda ValisoltaniDepartment of Clinical Nutrition, School of Nutrition Science and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
Sara KhoshdoozFaculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Saeid DoaeiDepartment of Community Nutrition, School of Nutrition and Food Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. sdoaee@yahoo.com.
Akram KooshkiNon-Communicable Diseases Research Center, Department of Nutrition & Biochemistry, School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, Iran. kooshki.nutr@gmail.com.
Maryam GholamalizadehCancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe association of hypertension (HTN) and different types of dietary amino acids is not yet clear. The aim of the present study was to investigate the association of branch chain amino acids (BCAAs) and the prevention of HTN.

methodsThis cross-sectional study was conducted on 4184 people aged 35 to 70 using data from the Sabzevar Persian cohort study in Sabzevar, Iran. Data on dietary intake of BCAAs including leucine, isoleucine, and valine were obtained using a validated Food Frequency Questionnaire (FFQ). Multivariable logistic regression analysis assessed the link between HTN and BCAAs.

resultsThe results showed that participants with HTN had a higher total protein and BCAAs intake than participants with normal BP (P < 0.01). A marginally significant association was found between the risk of HTN with the total intake of BCAAs (OR = 1.018, CI95%: 1.001-1.035, P = 0.04), leucine (OR = 1.040, CI95%:1.002-1.080, P = 0.03), isoleucine (OR = 1.068, CI95%:1.001-1.140, P = 0.04), and valine (OR = 1.060, CI95%:1.003-1.121, P = 0.04). However, the association disappeared after adjusting the total protein and calorie intake.

conclusionsThe results indicated that the dietary intake of BCAAs may be associated with the risk of HTN. Future longitudinal research is warranted.

Indexed as

Amino Acids, Branched-ChainBlood PressureHypertensionAdultAgedCross-Sectional StudiesDietary ProteinsFemaleHumansIranMaleMiddle AgedProtective FactorsRisk AssessmentRisk FactorsAmino Acids, Branched-ChainDietary ProteinsAmino acidsBlood pressureBranched-chain amino acidsHypertension

Identifiers

PMID39085768
PMCPMC11290056

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.