Evidence map›Paper›PMID 39086175›Full record

ReviewCardiovascular research2025

Neuroimmune circuits in the plaque and bone marrow regulate atherosclerosis.

Teresa Gerhardt, Pacific Huynh, Cameron S McAlpine

Abstract readReview
In one paragraph

Review in Cardiovascular research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Teresa GerhardtCardiovascular Research Institute and the Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Pacific HuynhCardiovascular Research Institute and the Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.
Cameron S McAlpineCardiovascular Research Institute and the Department of Medicine, Cardiology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.ORCID 0000-0002-9832-6345

Funding

The adaptive-innate immune interactome across multiple tissues in Alzheimer's diseaseR01AG082185 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI VAHRAM HAROUTUNIAN, Donghoon Lee · 2023 to 2026
$9.0M
Influence of sleep on the hematopoietic niche and atherosclerosis during agingR01HL158534 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MCALPINE, CAMERON STUART · 2021 to 2025
$2.1M
Influence of sleep on hematopoietic stem cell diversity and clonality in cardiovascular diseaseR00HL151750 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MCALPINE, CAMERON STUART · 2021 to 2023
$747k
Alzheimer's FundAmerican Heart Association Post-doctoral FellowshipCureGerman Research Foundation Walter Benjamin Fellowship 3588/1-1ISMMS Karen Strauss Cook Research Scholar AwardNHLBI NIH HHS R00 HL151750NHLBI NIH HHS R01 HL158534NIA NIH HHS R01 AG082185NIH HHS R01HL158534
6 · The paper itself

Abstract

Atherosclerosis remains the leading cause of death globally. Although its focal pathology is atheroma that develops in arterial walls, atherosclerosis is a systemic disease involving contributions by many organs and tissues. It is now established that the immune system causally contributes to all phases of atherosclerosis. Recent and emerging evidence positions the nervous system as a key modulator of inflammatory processes that underlie atherosclerosis. This neuroimmune cross-talk, we are learning, is bidirectional, and immune-regulated afferent signalling is becoming increasingly recognized in atherosclerosis. Here, we summarize data and concepts that link the immune and nervous systems in atherosclerosis by focusing on two important sites, the arterial vessel and the bone marrow.

Indexed as

ArteriesAtherosclerosisBone MarrowNeuroimmunomodulationPlaque, AtheroscleroticAnimalsHumansInflammation MediatorsSignal TransductionInflammation MediatorsAtherosclerosisHaematopoiesisLeucocytesLifestyleNervous systemNeuroimmunologyNeuropeptidesNeurotransmitters

Identifiers

PMID39086175
PMCPMC11976727

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.