Evidence map›Paper›PMID 39086274›Full record

ReviewEndocrinology and metabolism (Seoul, Korea)2024

Regulation of Energy and Glucose Homeostasis by the Nucleus of the Solitary Tract and the Area Postrema.

Kyla Bruce, Ameth N Garrido, Song-Yang Zhang, Tony K T Lam

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Endocrinology and metabolism (Seoul, Korea), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Brain circadian clocks timing the 24h rhythms of behavior.Npj biological timing and sleep · 2025
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kyla BruceInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Ameth N GarridoToronto General Hospital Research Institute, University Health Network (UHN), Toronto, ON, Canada.
Song-Yang ZhangToronto General Hospital Research Institute, University Health Network (UHN), Toronto, ON, Canada.
Tony K T LamInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.

Funding

Banting and Best Diabetes Center Graduate ScholarshipCIHRCIHR MRT-168045CIHR PJT 183901CIHR PJT 189957Ontario Graduate ScholarshipUniversity of Toronto
6 · The paper itself

Abstract

The central nervous system regulates feeding, weight and glucose homeostasis in rodents and humans, but the site-specific mechanisms remain unclear. The dorsal vagal complex in the brainstem that contains the nucleus of the solitary tract (NTS) and area postrema (AP) emerges as a regulatory center that impacts energy and glucose balance by monitoring hormonal and nutrient changes. However, the specific mechanistic metabolic roles of the NTS and AP remain elusive. This mini-review highlights methods to study their distinct roles and recent findings on their metabolic differences and similarities of growth differentiation factor 15 (GDF15) action and glucose sensing in the NTS and AP. In summary, future research aims to characterize hormonal and glucose sensing mechanisms in the AP and/or NTS carries potential to unveil novel targets that lower weight and glucose levels in obesity and diabetes.

Indexed as

Area PostremaEnergy MetabolismGlucoseHomeostasisSolitary NucleusAnimalsGrowth Differentiation Factor 15HumansGlucoseGrowth Differentiation Factor 15Area postremaEnergy metabolismFeedingGDF15GlucoseGlucose metabolismSolitary nucleus

Identifiers

PMID39086274
PMCPMC11377841

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.