Evidence mapPaperPMID 39088647Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2024

Maternal use of electronic cigarettes and impact on offspring: a double-hit model.

Amber Mills, Murugesan Velayutham, Debbie Corbin, Lindsey Suter, Madison Robinson, Valery V Khramtsov, Lainey Shouldis, Mary Cook, Duaa Dakhallah, Paul D Chantler and 1 more

Abstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Amber MillsDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, West Virginia, United States.ORCID 0000-0002-8898-7780
Murugesan VelayuthamCenter for Inhalation Toxicology, West Virginia University School of Medicine, Morgantown, West Virginia, United States.
Debbie CorbinDepartment of Neuroscience, West Virginia University School of Medicine, Morgantown, West Virginia, United States.
Lindsey SuterDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, West Virginia, United States.
Madison RobinsonDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, West Virginia, United States.
Valery V KhramtsovIn vivo Multifunctional Magnetic Resonance (IMMR) Center, West Virginia University School of Medicine, Morgantown, West Virginia, United States.ORCID 0000-0001-6187-5546
Lainey ShouldisDepartment of Microbiology, Immunology, and Cell Biology, West Virginia University School of Medicine, Morgantown, West Virginia, United States.
Mary CookDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, West Virginia, United States.
Duaa DakhallahDepartment of Surgery, West Virginia University School of Medicine, Morgantown, West Virginia, United States.
Paul D ChantlerDivision of Exercise Physiology, West Virginia University School of Medicine, Morgantown, West Virginia, United States.ORCID 0000-0001-6960-9728
I Mark OlfertDepartment of Physiology, Pharmacology, and Toxicology, West Virginia University School of Medicine, Morgantown, West Virginia, United States.ORCID 0000-0003-3505-9945

Funding

VS-CoBRE Administrative CoreP20GM144230 · NIGMS · WEST VIRGINIA UNIVERSITY · 2022 to 2025
$6.5M
West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve HealthU54GM104942 · WEST VIRGINIA UNIVERSITY · 2025 to 2025
$4.0M
Tumor Microenvironment-TME CoBREP20GM121322 · WEST VIRGINIA UNIVERSITY · 2025 to 2025
$2.2M
American Heart Association (AHA) CSA 20 35320107HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) 1R21-ES033026-01HHS | NIH | National Institute of Environmental Health Sciences (NIEHS) F31 ES034646-01HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM121322HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM144230HHS | NIH | National Institute of General Medical Sciences (NIGMS) U54-GM104942-05S1NIEHS NIH HHS F31 ES034646NIEHS NIH HHS R21 ES033026NIGMS NIH HHS P20 GM109098NIGMS NIH HHS P20 GM121322NIGMS NIH HHS P20 GM144230NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Endothelial dysfunction is a predictor for cardiovascular disease. Preclinical data suggest longstanding cardiovascular and cerebrovascular dysfunction occurs in offspring with perinatal electronic cigarette (Ecig) exposure. Furthermore, direct use of Ecigs increases reactive oxygen species and impairs cerebrovascular function, but the combined effect of direct use in offspring with a history of perinatal exposure (i.e. double-hit condition) is not known. We tested the hypothesis that offspring with double-hit Ecig exposure will lead to greater cerebrovascular and neurocognitive dysfunction compared with in utero exposure only. Male and female offspring were obtained from time-mated Sprague Dawley female rats exposed to air (

Indexed as

Electronic Nicotine Delivery SystemsPrenatal Exposure Delayed EffectsRats, Sprague-DawleyAnimalsFemaleMaleMaternal ExposureMiddle Cerebral ArteryOxidative StressPregnancyRatsVapingmiddle cerebral arteryoxidative stresspregnancyvaping

Identifiers

PMID39088647
PMCPMC11424175

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.