ArticleThe Journal of international medical research2024
Hypomethylated leptin receptor reduces cerebral ischaemia-reperfusion injury by activating the JAK2/STAT3 signalling pathway.
Article in The Journal of international medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Therapeutic Potential of Leptin in Neurodegenerative Disease.Biomedicines · 2025Review
- Preliminary insight into the potential role of Leptin Receptor Polymorphisms in Type 2 Diabetes Risk: case-control study and bioinformatics analysis.Journal of diabetes and metabolic disorders · 2025Article
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Authors and funding
8 authors.
Funding
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Abstract
objectiveTo investigate the cerebroprotective effects of leptin
methodsThe study used the cellular oxygen-glucose deprivation (OGD) model in PC12 cells and the middle cerebral artery occlusion (MCAO) rat model of cerebral ischaemia-reperfusion injury (CIRI) to assess changes in gene expression and protein levels following leptin pretreatment. The methylated DNA immunoprecipitation (MeDIP) assay measured DNA methylation levels.
resultsThe optimal leptin concentration for exerting neuroprotective effects against ischaemia-reperfusion injury in PC12 cells was 200 ng/ml
conclusionExogenous leptin might bind to extra-activated LEPR by reducing the methylation level of the
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