Evidence map›Paper›PMID 39090139›Full record

ArticleScientific reports2024

Exploring the interplay between antiretroviral therapy and the gut-oral microbiome axis in people living with HIV.

Aswathy Narayanan, Oscar Kieri, Jan Vesterbacka, Lokeshwaran Manoharan, Puran Chen, Mahin Ghorbani, Hans-Gustaf Ljunggren, Margaret Sällberg Chen, Soo Aleman, Anders Sönnerborg and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Aswathy NarayananDepartment of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden. aswathy.narayanan@ki.se.
Oscar KieriDepartment of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.
Jan VesterbackaDepartment of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.
Lokeshwaran ManoharanDepartment of Laboratory Medicine, National Bioinformatics Infrastructure Sweden (NBIS), SciLife, Lund University, Lund, Sweden.
Puran ChenDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden.
Mahin GhorbaniDepartment of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
Hans-Gustaf LjunggrenDepartment of Medicine Huddinge, Center for Infectious Medicine, Karolinska Institutet, Stockholm, Sweden.
Margaret Sällberg ChenDepartment of Dental Medicine, Karolinska Institutet, Stockholm, Sweden.
Soo AlemanDepartment of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.
Anders SönnerborgDepartment of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.
Shilpa Ray *Department of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden. shilpa.ray@ki.se.
Piotr Nowak *Department of Medicine Huddinge, Division of Infectious Diseases, Karolinska Institutet, Stockholm, Sweden.

Funding

Åke Wiberg Stiftelse M20-0171Karolinska Institutet 2021-00155Stiftelsen Läkare mot AIDS Forskningsfond FOa2021-0009Stiftelsen Läkare mot AIDS Forskningsfond FOb2020-0019Stockholm läns landsting ALF nr 20190451Vetenskapsrådet Dnr 2016-01675
6 · The paper itself

Abstract

The gut and oral microbiome is altered in people living with HIV (PLWH). While antiretroviral treatment (ART) is pivotal in restoring immune function in PLWH, several studies have identified an association between specific antiretrovirals, particularly integrase inhibitors (INSTI), and weight gain. In our study, we explored the differences in the oral and gut microbiota of PLWH under different ART regimens, and its correlation to Body Mass Index (BMI). Fecal and salivary samples were collected from PLWH (n = 69) and healthy controls (HC, n = 80). We performed taxonomy analysis to determine the microbial composition and relationship between microbial abundance and ART regimens, BMI, CD4

Indexed as

Gastrointestinal MicrobiomeHIV InfectionsAdultAnti-Retroviral AgentsBody Mass IndexFecesFemaleHumansMaleMiddle AgedMouthSalivaAnti-Retroviral AgentsBMIDolutegravir (DTG)Gut microbiotaIntegrase inhibitors (INSTIs)Oral microbiomePeople living with HIV (PLWH)

Identifiers

PMID39090139
PMCPMC11294597

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.