SynthesisBMC musculoskeletal disorders2024
Associations between lifestyle-related risk factors and back pain: a systematic review and meta-analysis of Mendelian randomization studies.
Synthesis in BMC musculoskeletal disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Type 2 diabetes mellitus and cancer: A systematic review and meta-analysis of Mendelian randomization studies.Frontiers in endocrinology · 2026Pooled it
- Research advances in physical activity and insomnia: a bibliometric and thematic evolution analysis.Frontiers in psychiatry · 2026Pooled it
- Artificial Intelligence in Spine Neuroimaging: Diagnostic and Prognostic Utility of Novel Biomarkers in Lower Back Pain.Journal of clinical medicine · 2026Review
- Improved Chronic Low Back Pain, Radiographic Alignment, and Patient Reported Outcomes Following Postural Rehabilitation Protocols: A Case Series of Two Patients with 18- and 26-Months Follow-Up.Healthcare (Basel, Switzerland) · 2026Article
- Implementation status and barriers to multimodal management of low back pain among physical therapists: A cross-sectional study.Scientific reports · 2026Article
- Article
- Association between lifestyle habits and central sensitization in community-dwelling older adults in Japan: a cross-sectional analysis from the Otassha study.BMC geriatrics · 2026Article
- The association between age at menarche and subsequent risk of chronic pain.Frontiers in global women's health · 2026Review
- Article
- Causal Risk Factors for Type 1 Diabetes in Mendelian Randomization Studies: A Systematic Review and Meta-Analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Review
- Associations of physical activity and sedentary behavior with chronic low back pain in middle-aged and older adults: a cross-sectional study.Frontiers in public health · 2026Article
- Association between eveningness and low back pain among public servants in Japan: a cross-sectional analysis of the Aichi Workers' Cohort Study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Effects of Malnutrition on the Incidence and Worsening of Frailty in Community-Dwelling Older Adults with Pain.Nutrients · 2025Article
- Innovative Approaches for the Treatment of Spinal Disorders: A Comprehensive Review.Journal of orthopaedics and sports medicine · 2025Article
- Global, regional, and national burden and trends of Low back pain in middle-aged adults: analysis of GBD 1990-2021 with projections to 2050.BMC musculoskeletal disorders · 2024Article
- Are the Previously Reported Risk Factors for Endometriosis Actually Associated With Pain and Infertility Rather Than Endometriosis Itself?Reproductive medicine and biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMendelian randomization (MR) studies have an advantage over conventional observational studies when studying the causal effect of lifestyle-related risk factors on back pain. However, given the heterogeneous design of existing MR studies on back pain, the reported causal estimates of these effects remain equivocal, thus obscuring the true extent of the biological effects of back pain lifestyle-risk factors. PURPOSE: The purpose of this study was to conduct a systematic review with multiple meta-analyses on the associations between various lifestyle factors and low back pain.
methodsWe conducted a PRISMA systematic review and specifically included MR studies to investigate the associations between lifestyle factors-specifically, BMI, insomnia, smoking, alcohol consumption, and leisure sedentary behavior-and various back pain outcomes. Each meta-analysis synthesized data from three or more studies to assess the causal impact of these exposures on distinct back pain outcomes, including chronic pain, disability, and pain severity. Quality of studies was assessed according to STROBE-MR guidelines.
resultsA total of 1576 studies were evaluated and 20 were included. Overall, the studies included were of high quality and had a low risk of bias. Our meta-analysis demonstrates the positive causal effect of BMI (OR
conclusionIn light of the disparate designs and causal effect estimates presented in numerous MR studies, our meta-analysis establishes a compelling argument that lifestyle-related risk factors such as BMI, insomnia, smoking, alcohol consumption, and leisure sedentary behaviors genuinely contribute to the biological development of back pain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.