Evidence map›Paper›PMID 39091463›Full record

ArticleiScience2024

Multi-omic profiling of pathogen-stimulated primary immune cells.

Renee Salz, Emil E Vorsteveld, Caspar I van der Made, Simone Kersten, Merel Stemerdink, Tabea V Riepe, Tsung-Han Hsieh, Musa Mhlanga, Mihai G Netea, Pieter-Jan Volders and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Renee SalzDepartment of Medical BioSciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Emil E VorsteveldRadboudUMC Research Institute for Medical Innovation, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Caspar I van der MadeRadboudUMC Research Institute for Medical Innovation, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Simone KerstenRadboudUMC Research Institute for Medical Innovation, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Merel StemerdinkRadboudUMC Research Institute for Medical Innovation, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Tabea V RiepeDepartment of Medical BioSciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Tsung-Han HsiehDepartment of Cell Biology, Radboud University, 6500 HB Nijmegen, the Netherlands.
Musa MhlangaRadboudUMC Research Institute for Medical Innovation, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Mihai G NeteaDepartment of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Pieter-Jan VoldersDepartment of Biomolecular Medicine, Ghent University, Ghent, Belgium.
Alexander HoischenRadboudUMC Research Institute for Medical Innovation, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.
Peter A C 't HoenDepartment of Medical BioSciences, Radboud University Medical Center, 6525 GA Nijmegen, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We performed long-read transcriptome and proteome profiling of pathogen-stimulated peripheral blood mononuclear cells (PBMCs) from healthy donors to discover new transcript and protein isoforms expressed during immune responses to diverse pathogens. Long-read transcriptome profiling reveals novel sequences and isoform switching induced upon pathogen stimulation, including transcripts that are difficult to detect using traditional short-read sequencing. Widespread loss of intron retention occurs as a common result of all pathogen stimulations. We highlight novel transcripts of

Indexed as

ImmunologyProteomicsTranscriptomics

Identifiers

PMID39091463
PMCPMC11293528

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.