Evidence map›Paper›PMID 39091504›Full record

ArticleFrontiers in immunology2024

Tetanus-diphtheria vaccine can prime SARS-CoV-2 cross-reactive T cells.

Sara Alonso Fernandez, Hector F Pelaez-Prestel, Tara Fiyouzi, Marta Gomez-Perosanz, Jesús Reiné, Pedro A Reche

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sara Alonso Fernandez *Department of Immunology & O2, Faculty of Medicine, Complutense University of Madrid, Ciudad Universitaria, Madrid, Spain.
Hector F Pelaez-Prestel *Department of Immunology & O2, Faculty of Medicine, Complutense University of Madrid, Ciudad Universitaria, Madrid, Spain.
Tara Fiyouzi *Department of Immunology & O2, Faculty of Medicine, Complutense University of Madrid, Ciudad Universitaria, Madrid, Spain.
Marta Gomez-PerosanzDepartment of Immunology & O2, Faculty of Medicine, Complutense University of Madrid, Ciudad Universitaria, Madrid, Spain.
Jesús ReinéClinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Pedro A RecheDepartment of Immunology & O2, Faculty of Medicine, Complutense University of Madrid, Ciudad Universitaria, Madrid, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaccines containing tetanus-diphtheria antigens have been postulated to induce cross-reactive immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which could protect against coronavirus disease (COVID-19). In this work, we investigated the capacity of Tetanus-diphtheria (Td) vaccine to prime existing T cell immunity to SARS-CoV-2. To that end, we first collected known SARS-CoV-2 specific CD8

Indexed as

CD8-Positive T-LymphocytesCOVID-19Cross ReactionsEpitopes, T-LymphocyteSARS-CoV-2AdultAnimalsCOVID-19 VaccinesFemaleHumansMaleMiceMiddle AgedSpike Glycoprotein, CoronavirusTetanus ToxoidCOVID-19 VaccinesEpitopes, T-LymphocyteSpike Glycoprotein, CoronavirusTetanus ToxoidCOVID-19epitopeSARS-CoV-2T cell cross-reactivitytetanus-diphtheria toxoid vaccines

Identifiers

PMID39091504
PMCPMC11291333

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.