Evidence mapPaperPMID 39091582Full record

ArticleOncology letters2024

Sonic hedgehog expression in steatohepatitic hepatocellular carcinoma and its clinicopathological significance.

Hironori Kusano, Sachiko Ogasawara, Minori Omuraya, Masayuki Okudaira, Shinji Mizuochi, Yutaro Mihara, Yoshinao Kinjo, Yuta Yano, Masamichi Nakayama, Reiichiro Kondo and 4 more

Abstract read
In one paragraph

Article in Oncology letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hironori KusanoDepartment of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Sachiko OgasawaraDepartment of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Minori OmurayaOmuta City Hospital, Omuta, Fukuoka 836-8567, Japan.
Masayuki OkudairaNHO Nagasaki Medical Center, Omura, Fukuoka 856-0835, Japan.
Shinji MizuochiDepartment of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Yutaro MiharaDepartment of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Yoshinao KinjoDepartment of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Yuta YanoDepartment of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Masamichi NakayamaDepartment of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Reiichiro KondoDepartment of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.
Yoshiki NaitoDepartment of Clinical Laboratory Medicine, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan.
Jun AkibaDepartment of Diagnostic Pathology, Kurume University Hospital, Kurume, Fukuoka 830-0011, Japan.
Osamu NakashimaDepartment of Clinical Laboratory, St Mary's Hospital, Kurume, Fukuoka 830-8543, Japan.
Hirohisa YanoDepartment of Pathology, Kurume University School of Medicine, Kurume, Fukuoka 830-0011, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hedgehog (Hh) signaling pathway dysregulation is involved in the pathogenesis of metabolic dysfunction-associated steatohepatitis, and the sonic Hh (SHh) protein, a pivotal molecule in the Hh pathway, is expressed in ballooned hepatocytes. The present study aimed to investigate the clinicopathological significance of SHh expression in steatohepatitic hepatocellular carcinoma (SH-HCC). Reverse transcription-quantitative polymerase chain reaction and immunohistochemistry were performed to examine

Indexed as

hedgehog signaling pathwayhepatocellular carcinomaprimary liver cancersonic hedgehogsteatohepatitic hepatocellular carcinomasteatohepatitis

Identifiers

PMID39091582
PMCPMC11292461

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.