Evidence map›Paper›PMID 39091735›Full record

ArticlebioRxiv : the preprint server for biology2024

Bone mineral density affects tumor growth by shaping microenvironmental heterogeneity.

Matthew A Whitman, Madhav Mantri, Emmanuel Spanos, Lara A Estroff, Iwijn De Vlaminck, Claudia Fischbach

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Matthew A WhitmanNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14850.ORCID 0000-0002-5399-5318
Madhav MantriNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14850.ORCID 0000-0001-9844-7852
Emmanuel SpanosNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14850.ORCID 0009-0005-5345-6807
Lara A EstroffDepartment of Materials Science and Engineering, Cornell University, Ithaca, NY 14850.ORCID 0000-0002-7658-1265
Iwijn De VlaminckNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14850.ORCID 0000-0001-6085-7311
Claudia FischbachNancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University, Ithaca, New York 14850.ORCID 0000-0002-9368-0150

Funding

NCI NIH HHS U54 CA210184NIH HHS S10 OD025049
6 · The paper itself

Abstract

Breast cancer bone metastasis is the leading cause of mortality in patients with advanced breast cancer. Although decreased mineral density is a known risk factor for bone metastasis, the underlying mechanisms remain poorly understood because studying the isolated effect of bone mineral density on tumor heterogeneity is challenging with conventional approaches. Here, we investigate how bone mineral content affects tumor growth and microenvironmental complexity

Identifiers

PMID39091735
PMCPMC11291034

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.