ArticlebioRxiv : the preprint server for biology2024
A high-performance genetically encoded sensor for cellular imaging of PKC activity
Takaki Yahiro, Landon Bayless-Edwards, James A Jones, Lei Ma, Maozhen Qin, Tianyi Mao, Haining Zhong
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
7 authors.
Takaki YahiroVollum Institute, Oregon Health and Science University, Portland, OR, 97239.
Landon Bayless-EdwardsVollum Institute, Oregon Health and Science University, Portland, OR, 97239.
James A JonesVollum Institute, Oregon Health and Science University, Portland, OR, 97239.
Lei MaVollum Institute, Oregon Health and Science University, Portland, OR, 97239.
Maozhen QinVollum Institute, Oregon Health and Science University, Portland, OR, 97239.
Tianyi MaoVollum Institute, Oregon Health and Science University, Portland, OR, 97239.
Haining ZhongVollum Institute, Oregon Health and Science University, Portland, OR, 97239.
Funding
Multiplex imaging of neuronal activity and signaling dynamics underlying learning in discrete amygdala circuits of behaving mice.R01NS104944 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LI, BO, MAO, TIANYI · 2018 to 2022
$5.0MGenetic and physiological dissection of the circuit mechanisms in the striatum.R01NS081071 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MAO, TIANYI · 2013 to 2023
$3.6MSensing and manipulating neuromodulatory signaling in vivoRF1MH130784 · NIMH · OREGON HEALTH & SCIENCE UNIVERSITY · PI ZHONG, HAINING · 2023 to 2023
$2.6MNeuromodulation in the striatumR01NS127013 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Haining Zhong · 2022 to 2026
$1.9MIntracellular signaling mechanisms underlying opioid modulation of painF30DA057838 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Landon Bayless-Edwards · 2023 to 2026
$203kNIDA NIH HHS F30 DA057838NIMH NIH HHS RF1 MH130784NINDS NIH HHS R01 NS081071NINDS NIH HHS R01 NS104944NINDS NIH HHS R01 NS127013
6 · The paper itselfAbstract
We report a genetically encoded fluorescence lifetime sensor for protein kinase C (PKC) activity, named CKAR3, based on Förster resonance energy transfer. CKAR3 exhibits a 10-fold increased dynamic range compared to its parental sensors and enables
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PMID39091834
PMCPMC11291028
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