Evidence map›Paper›PMID 39091890›Full record

ArticlebioRxiv : the preprint server for biology2024

Stimulation of locus coeruleus inputs to the frontal cortex in mice induces cell type-specific expression of the

Genevieve E Craig, Lizbeth Ramos, Samuel R Essig, Nicholas J Eagles, Andrew E Jaffe, Keri Martinowich, Henry L Hallock

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Genevieve E CraigNeuroscience Program, Lafayette College, Easton, PA, 18042, USA.
Lizbeth RamosNeuroscience Program, Lafayette College, Easton, PA, 18042, USA.
Samuel R EssigNeuroscience Program, Lafayette College, Easton, PA, 18042, USA.
Nicholas J EaglesLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.
Andrew E JaffeLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.
Keri MartinowichLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, 21205, USA.
Henry L HallockNeuroscience Program, Lafayette College, Easton, PA, 18042, USA.

Funding

Regulation of neural activity in fear circuits by promoter IV derived BDNFR01MH105592 · NIMH · LIEBER INSTITUTE, INC. · PI MARTINOWICH, KERI · 2015 to 2024
$5.6M
Molecular, cellular and physiological correlates of sustained attention in the locus coeruleus to anterior cingulate cortex circuitR21MH130066 · NIMH · LIEBER INSTITUTE, INC. · PI HALLOCK, HENRY L, MARTINOWICH, KERI · 2023 to 2023
$444k
NIMH NIH HHS R01 MH105592NIMH NIH HHS R21 MH130066
6 · The paper itself

Abstract

Deficits in attention are common across a range of neuropsychiatric disorders. A multitude of brain regions, including the frontal cortex (FC) and locus coeruleus (LC), have been implicated in attention. Regulators of these brain regions at the molecular level are not well understood, but might elucidate underlying mechanisms of disorders with attentional deficits. To probe this, we used chemogenetic stimulation of neurons in the LC with axonal projections to the FC, and subsequent bulk RNA-sequencing from the mouse FC. We found that stimulation of this circuit caused an increase in transcription of the

Identifiers

PMID39091890
PMCPMC11291023

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.