Evidence map›Paper›PMID 39092138›Full record

ArticleBiological psychiatry global open science2024

Transcranial Focused Ultrasound Targeting the Amygdala May Increase Psychophysiological and Subjective Negative Emotional Reactivity in Healthy Older Adults.

Bianca Hoang-Dang, Sabrina E Halavi, Natalie M Rotstein, Norman M Spivak, Nolan H Dang, Luka Cvijanovic, Sonja H Hiller, Mauricio Vallejo-Martelo, Benjamin M Rosenberg, Andrew Swenson and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biological psychiatry global open science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Noninvasive Suppression of Responses to Threat Using Focused Ultrasonic Waves.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Targeting Deep Structures to Noninvasively Modulate Fear and Anxiety.Biological psychiatry global open science · 2024
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Bianca Hoang-DangDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Sabrina E HalaviDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Natalie M RotsteinDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Norman M SpivakDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Nolan H DangDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Luka CvijanovicNeuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, California.
Sonja H HillerDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Mauricio Vallejo-MarteloDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Benjamin M RosenbergDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
Andrew SwensonNeuroscience Interdepartmental Program, University of California, Los Angeles, Los Angeles, California.
Sergio BecerraDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Michael SunDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
Malina E RevettDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
David KronemyerDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Rustin BerlowAmerican Brain Stimulation Clinic, Del Mar, California.
Michelle G CraskeDepartment of Psychology, University of California, Los Angeles, Los Angeles, California.
Nanthia SuthanaDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Martin M MontiDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Tomislav D ZbozinekDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Susan Y BookheimerDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.
Taylor P KuhnDepartment of Psychiatry and Behavioral Sciences, University of California, Los Angeles, Los Angeles, California.

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
The effects and neural correlates of combined conscious fear control and extinction learning on fear reduction and relapseF31MH111199 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUN, MICHAEL · 2017 to 2018
$47k
NIGMS NIH HHS T32 GM008042NIMH NIH HHS F31 MH111199
6 · The paper itself

Abstract

Background: The amygdala is highly implicated in an array of psychiatric disorders but is not accessible using currently available noninvasive neuromodulatory techniques. Low-intensity transcranial focused ultrasound (TFUS) is a neuromodulatory technique that has the capability of reaching subcortical regions noninvasively. Methods: We studied healthy older adult participants ( Results: Significant increases in both self-reported arousal in response to negative images and heart rate during emotional reactivity and regulation task intertrial intervals were observed when TFUS targeted the amygdala; these changes were not evident when the entorhinal cortex was targeted. No significant changes were found for state anxiety, self-reported valence to the negative images, cardiac response to the negative images, or emotion regulation. Conclusions: The results of this study provide preliminary evidence that a single session of TFUS targeting the amygdala may alter psychophysiological and subjective emotional responses, indicating some potential for future neuropsychiatric applications. However, more work on TFUS parameters and targeting optimization is necessary to determine how to elicit changes in a more clinically advantageous way.

Indexed as

AmygdalaEmotional reactivityLow-intensity transcranial focused ultrasound (TFUS)Noninvasive deep brain stimulationPsychophysiology

Identifiers

PMID39092138
PMCPMC11293512

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.