Evidence map›Paper›PMID 39093000›Full record

ReviewAmerican journal of physiology. Heart and circulatory physiology2024

Cardiac fibroblasts: answering the call.

Petra Kleinbongard, Samuel E Senyo, Merry L Lindsey, Alexandra M Garvin, Jeremy A Simpson, Lisandra E de Castro Braz

Abstract readReview
In one paragraph

Review in American journal of physiology. Heart and circulatory physiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. The Role of Thrombospondin-2 in Myocardial Fibrosis.Drug design, development and therapy · 2026
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Petra KleinbongardInstitute for Pathophysiology, West German Heart and Vascular Center, University of Essen Medical School, University of Duisburg-Essen, Essen, Germany.ORCID 0000-0003-3576-3772
Samuel E SenyoDepartment of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States.ORCID 0000-0002-9206-6845
Merry L LindseySchool of Graduate Studies, Meharry Medical College, Nashville, Tennessee, United States.ORCID 0000-0002-4090-0391
Alexandra M GarvinDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States.ORCID 0000-0002-5784-5587
Jeremy A SimpsonDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.ORCID 0000-0003-4482-547X
Lisandra E de Castro BrazDepartment of Physiology, Brody School of Medicine, East Carolina University, Greenville, North Carolina, United States.

Funding

Study of AR transcriptional network in stem cell model of SBMAR01NS121374 · NINDS · CASE WESTERN RESERVE UNIVERSITY · PI MIRANDA, HELEN C · 2021 to 2025
$2.0M
Short Course In Transferable Skills Training (SHIFT) ProgramR25GM151274 · NIGMS · MEHARRY MEDICAL COLLEGE · PI MERRY L. LINDSEY, Pius N Nde · 2023 to 2026
$1.9M
Collagen-derived peptides to target inflammation in myocardial infarctionR01HL152297 · NHLBI · EAST CAROLINA UNIVERSITY · PI DE CASTRO BRAZ, LISANDRA E · 2022 to 2025
$1.5M
Collagen-derived peptides to target inflammation in myocardial infarctionR56HL152297 · NHLBI · EAST CAROLINA UNIVERSITY · PI DE CASTRO BRAZ, LISANDRA E · 2020 to 2020
$366k
2022 American Society for Matrix Biology Workshop on Fibroblasts: The Many Faces of FibroblastsR13HL165779 · NHLBI · UNIVERSITY OF VIRGINIA · PI BARKER, THOMAS HARRISON · 2022 to 2022
$10k
Heart Failure: All Cells ConsideredR13HL168861 · NHLBI · KEYSTONE SYMPOSIA · PI SHEPPARD, TERRY L. · 2023 to 2023
$10k
BLRD VA I01 BX000505HHS | National Institutes of Health (NIH) GM151274HHS | National Institutes of Health (NIH) HL152297HHS | National Institutes of Health (NIH) HL165779HHS | National Institutes of Health (NIH) HL168861HHS | National Institutes of Health (NIH) NS121374NHLBI NIH HHS R01 HL152297NHLBI NIH HHS R13 HL165779NHLBI NIH HHS R13 HL168861NHLBI NIH HHS R56 HL152297NIGMS NIH HHS R25 GM151274NINDS NIH HHS R01 NS121374U.S. Department of Veterans Affairs (VA) 5I01BX000505
6 · The paper itself

Abstract

Cardiac fibroblasts play a pivotal role in maintaining heart homeostasis by depositing extracellular matrix (ECM) to provide structural support for the myocardium, vasculature, and neuronal network and by contributing to essential physiological processes. In response to injury such as myocardial infarction or pressure overload, fibroblasts become activated, leading to increased ECM production that can ultimately drive left ventricular remodeling and progress to heart failure. Recently, the

Indexed as

Extracellular MatrixFibroblastsMyocardiumAnimalsHumansSignal TransductionVentricular Remodelingfibrosisischemiamyocardiumphysiologypressure overload

Identifiers

PMID39093000
PMCPMC11442096

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.