Evidence map›Paper›PMID 39093436›Full record

ReviewFuture cardiology2024

Does one size really fit all? The case for personalized antiplatelet therapy in interventional cardiology.

Ahmed Elserwey, Richard J Jabbour, Nick Curzen

Abstract readReview
In one paragraph

Review in Future cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ahmed ElserweyFaculty of Medicine, University of Southampton.ORCID 0000-0002-8274-8981
Richard J JabbourUniversity Hospital Southampton NHS FT.ORCID 0000-0002-9028-2413
Nick CurzenFaculty of Medicine, University of Southampton.ORCID 0000-0001-9651-7829

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease is the leading cause of death worldwide. Dual antiplatelet therapy (DAPT), with aspirin plus a P2Y12 inhibitor, is currently recommended as a default for patients after acute coronary syndrome (ACS) and following percutaneous coronary intervention (PCI). However, controversies arise over the role of aspirin, the optimal duration of DAPT after drug-eluting stent (DES) implantation, the choice of P2Y12 inhibitor and the variability in individual responses to antiplatelet agents. Recent data indicate that monotherapy with a P2Y12 inhibitor may have adequate anti-ischemic effects with lower bleeding risk. Additionally, discrepancies in DAPT duration recommendations and the optimal P2Y12 inhibitor, provides more uncertainty. We ask the question "does one size really fits all?" or should a more personalized strategy should be implemented.

Indexed as

Percutaneous Coronary InterventionPlatelet Aggregation InhibitorsPrecision MedicineAcute Coronary SyndromeAspirinDrug-Eluting StentsDual Anti-Platelet TherapyHumansPurinergic P2Y Receptor AntagonistsAspirinPlatelet Aggregation InhibitorsPurinergic P2Y Receptor Antagonistsacute coronary syndromeantiplateletsCYP2C19 LOFgenotypeischemic heart diseasepersonalized antiplatelet therapyphenotypeplatelet function testingTEG 6S

Identifiers

PMID39093436
PMCPMC11485715

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.