Evidence map›Paper›PMID 39093477›Full record

ArticleBulletin of experimental biology and medicine2024

Protein Kinase A Inhibitor Attenuates the Antinociceptive Effect of NMDA-Receptor Channel Antagonists in the Capsaicin Test in Mice.

E A Ivanova, A G Vasilchuk, T A Voronina

Abstract read
PubMed Publisher
In one paragraph

Article in Bulletin of experimental biology and medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

E A IvanovaV. V. Zakusov Research Institute of Pharmacology, Moscow, Russia. iwanowaea@yandex.ru.
A G VasilchukV. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
T A VoroninaV. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Acute nociceptive pain in mice caused by subcutaneous (intraplantar) injection of TRPV1 ion channel agonist capsaicin (1.6 μg/mouse) and the effects of protein kinase A inhibitor H-89 (0.05 mg/mouse, intraplantar injection) and NMDA receptor channel antagonists MK-801 (7.5 and 15 μg/mouse, topical application) and hemantane (0.5 mg/mouse, topical application) on the pain were assessed. MK-801 and hemantane were found to reduce the duration of the pain response. H-89 did not significantly affect the pain in animals, but preliminary administration of this drug abolished the antinociceptive effect of MK-801 (7.5 μg/mouse) and weakens the effect of hemantane (0.5 mg/mouse).

Indexed as

AnalgesicsCapsaicinDizocilpine MaleateReceptors, N-Methyl-D-AspartateAnimalsCyclic AMP-Dependent Protein KinasesMaleMiceNociceptive PainPain MeasurementProtein Kinase InhibitorsTRPV Cation ChannelsAnalgesicsCapsaicinCyclic AMP-Dependent Protein KinasesDizocilpine MaleateProtein Kinase InhibitorsReceptors, N-Methyl-D-AspartateTRPV1 protein, mouseTRPV Cation ChannelsmiceNMDA receptornociceptive painprotein kinase ATRPV1 ion channel

Identifiers

PMID39093477

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.