Evidence map›Paper›PMID 39093548›Full record

ArticleTissue engineering and regenerative medicine2024

Rapamycin Attenuates H

Yuyang Tang, Sen Yang, Zhen Qiu, Li Guan, Yigui Wang, Guixin Li, Yuanyu Tu, Lijuan Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering and regenerative medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yuyang TangSchool of Stomatology, Zunyi Medical University, Zunyi, China.
Sen YangDepartment of Stomatology, Suining Central Hospital, Suining, China.
Zhen QiuSchool of Stomatology, Zunyi Medical University, Zunyi, China.
Li GuanSchool of Stomatology, Zunyi Medical University, Zunyi, China.
Yigui WangNursing School, Zunyi Medical University, Zunyi, China.
Guixin LiSchool of Stomatology, Southwest Medical University, Luzhou, China.
Yuanyu TuDepartment of Stomatology, Suining Central Hospital, Suining, China.
Lijuan GuoSchool of Stomatology, Zunyi Medical University, Zunyi, China. 663418587@QQ.com.ORCID 0009-0009-3289-5631

Funding

Primary Health Development Research Center of Sichuan Province Program SWFZ20-C-086Provincial Science and Technology Plan Project of Sichuan Provincial Department of Science and Technology Provincial ScienceProvincial Science and Technology Plan Project of Sichuan Provincial Department of Science and Technology TechnologyProvincial Science and Technology Plan Project of Sichuan Provincial Department of Science and Technology Technology Plan Project of Sichuan Provincial Department of ScienceScience and Technology Project of Sichuan Provincial Health Commission (Appropriate Technology Base) 2022JDXM021Sichuan Provincial Administration of Traditional Chinese Medicine 2021MS100Sichuan Transfer Project 2021SNZY001
6 · The paper itself

Abstract

backgroundOxidative stress plays an important role in the skin aging process. Rapamycin has been shown to have anti-aging effects, but its role in oxidative senescence of skin cells remains unclear. The aim of this study was to explore the effect of rapamycin on oxidative stress-induced skin cell senescence and to illustrate the mechanism.

methodsPrimary human skin fibroblasts (HSFs) were extracted and a model of H

resultsRapamycin (0.1 nmol/L for 48 h) promoted the proliferative and migration of H

conclusionOur findings indicate that rapamycin shields HSFs from H

Indexed as

AutophagyCellular SenescenceFibroblastsHydrogen PeroxideOxidative StressSirolimusSkinCell MovementCell ProliferationCells, CulturedHumansReactive Oxygen SpeciesHydrogen PeroxideReactive Oxygen SpeciesSirolimusAutophagyHuman skin fibroblastsOxidative stressRapamycinSenescence

Identifiers

PMID39093548
PMCPMC11416443

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.