Evidence map›Paper›PMID 39095010›Full record

ArticleThe Journal of pediatrics2024

Validation of Variables for Use in Pediatric Obesity Risk Score Development in Demographically and Racially Diverse United States Cohorts.

Castle J Funatake, Marcos Armendáriz, Stephen Rauch, Brenda Eskenazi, Yoko Nomura, Marie-France Hivert, Sheryl Rifas-Shiman, Emily Oken, Stephen C Shiboski, Janet M Wojcicki

Abstract readValidation Study
In one paragraph

Article in The Journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Castle J FunatakeDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California, San Francisco, San Francisco, CA.
Marcos ArmendárizDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California, San Francisco, San Francisco, CA.
Stephen RauchCenter for Environmental Research and Children's Health, University of California, Berkeley, Berkeley, CA.
Brenda EskenaziCenter for Environmental Research and Children's Health, University of California, Berkeley, Berkeley, CA.
Yoko NomuraDepartment of Psychology, Queens College and Graduate Center, the City University of New York (CUNY), New York, NY; Icahn School of Medicine at Mount Sinai, Department of Psychiatry, New York, NY.
Marie-France HivertDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA.
Sheryl Rifas-ShimanDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA.
Stephen C ShiboskiDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA.
Janet M WojcickiDivision of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of California, San Francisco, San Francisco, CA; Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA. Electronic address: Janet.Wojcicki@ucsf.edu.

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Project C: Epigenetic Effects of DDT/E and PBDEs on PubertyP01ES009605 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ESKENAZI, BRENDA · 1999 to 2015
$11.2M
Epigenetic susceptibility of behavioral and addictive disorders during pre/pubescence after natural disaster exposures in-uteroR01DA057310 · NIDA · QUEENS COLLEGE · PI Yoko Nomura · 2023 to 2026
$3.9M
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescenceR24ES030894 · NIEHS · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2020 to 2024
$2.0M
Maintaining and Expanding the CHAMACOS Epidemiology Cohort Infrastructure for Future GenerationsR24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Robert Gunier · 2017 to 2026
$2.0M
Structural studies of RNA polymerase regulation by RNAR01GM097458 · NIGMS · ROCKEFELLER UNIVERSITY · PI DARST, SETH A. · 2012 to 2015
$1.3M
Fostering Scientific and Workforce Diversity by Maintaining and Enriching the CHAMACOS Birth CohortU24ES028529 · NIEHS · UNIVERSITY OF CALIFORNIA BERKELEY · PI GUNIER, ROBERT · 2023 to 2025
$1.1M
Maternal Depression and Child Weight Gain in a Latino CohortK01DK080825 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WOJCICKI, JANET M · 2009 to 2014
$721k
NICHD NIH HHS R01 HD034568NIDA NIH HHS R01 DA057310NIDDK NIH HHS K01 DK080825NIEHS NIH HHS P01 ES009605NIEHS NIH HHS R24 ES028529NIEHS NIH HHS R24 ES030894NIEHS NIH HHS U24 ES028529NIGMS NIH HHS R01 GM097458NIH HHS UH3 OD023286
6 · The paper itself

Abstract

objectiveTo evaluate the performance of childhood obesity prediction models in four independent cohorts in the United States, using previously validated variables obtained easily from medical records as measured in different clinical settings. STUDY

designData from four prospective cohorts, Latinx, Eating, and Diabetes; Stress in Pregnancy Study; Project Viva; and Center for the Health Assessment of Mothers and Children of Salinas were used to test childhood obesity risk models and predict childhood obesity by ages 4 through 6, using five clinical variables (maternal age, maternal prepregnancy body mass index, birth weight Z-score, weight-for-age Z-score change, and breastfeeding), derived from a previously validated risk model and as measured in each cohort's clinical setting. Multivariable logistic regression was performed within each cohort, and performance of each model was assessed based on discrimination and predictive accuracy.

resultsThe risk models performed well across all four cohorts, achieving excellent discrimination. The area under the receiver operator curve was 0.79 for Center for the Health Assessment of Mothers and Children of Salinas and Project Viva, 0.83 for Stress in Pregnancy Study, and 0.86 for Latinx, Eating, and Diabetes. At a 50th percentile threshold, the sensitivity of the models ranged from 12% to 53%, and specificity was ≥ 90%. The negative predictive values were ≥ 80% for all cohorts, and the positive predictive values ranged from 62% to 86%.

conclusionAll four risk models performed well in each independent and demographically diverse cohort, demonstrating the utility of these five variables for identifying children at high risk for developing early childhood obesity in the United States.

Indexed as

Pediatric ObesityAdultBirth WeightBody Mass IndexChildChild, PreschoolCohort StudiesFemaleHumansMalePregnancyProspective StudiesRisk AssessmentRisk FactorsUnited Statesearly childhood obesityrisk model

Identifiers

PMID39095010
PMCPMC12700563

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.