ArticleNature communications2024
A kinase fusion protein from Aegilops longissima confers resistance to wheat powdery mildew.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Fine mapping of a powdery mildew resistance gene PmCWI16926 from cultivated emmer wheat.Communications biology · 2026Article
- Fine mapping and candidate gene dissection of the wheat powdery mildew resistance gene PmPBDH.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- Pm37 as a susceptible Sr22 allele confers resistance to wheat powdery mildew and leaf rust.Nature communications · 2026Article
- Identification of genetic loci and candidate genes underlying sharp eyespot resistance in wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- An NLR pair in the Pm68 locus confers powdery mildew resistance in durum and common wheat.Nature communications · 2025Article
- Two complementary NLRs from wild emmer wheat confer powdery mildew resistance.Nature communications · 2025Article
- Foliar disease resistance phenomics of fungal pathogens: image-based approaches for mapping quantitative resistance in cereal germplasm.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- Fine mapping of a novel powdery mildew resistance gene PmDM8 derived from a cultivated emmer (Triticum dicoccum).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Agricultural biotechnology in China: product development, commercialization, and perspectives.aBIOTECH · 2025Review
- Fine mapping ofMolecular breeding : new strategies in plant improvement · 2025Article
- An optimized disease resistance gene cloning workflow for wheat.Nature communications · 2025Article
- Development and characterization of small translocations between the Pm13 introgression from Aegilops longissima and wheat homoeologous A, B and D chromosomes.BMC plant biology · 2025Article
- Article
- Molecular identification of a Pm4 allele conferring powdery mildew resistance in durum wheat DR88.BMC plant biology · 2024Article
- Fine-mapping ofFrontiers in plant science · 2024Article
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16 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Many disease resistance genes have been introgressed into wheat from its wild relatives. However, reduced recombination within the introgressed segments hinders the cloning of the introgressed genes. Here, we have cloned the powdery mildew resistance gene Pm13, which is introgressed into wheat from Aegilops longissima, using a method that combines physical mapping with radiation-induced chromosomal aberrations and transcriptome sequencing analysis of ethyl methanesulfonate (EMS)-induced loss-of-function mutants. Pm13 encodes a kinase fusion protein, designated MLKL-K, with an N-terminal domain of mixed lineage kinase domain-like protein (MLKL_NTD domain) and a C-terminal serine/threonine kinase domain bridged by a brace. The resistance function of Pm13 is validated through transient and stable transgenic complementation assays. Transient over-expression analyses in Nicotiana benthamiana leaves and wheat protoplasts reveal that the fragment Brace-Kinase
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