Evidence mapPaperPMID 39096536Full record

ReviewJournal of molecular and cellular cardiology2024

NAD metabolism and heart failure: Mechanisms and therapeutic potentials.

Matthew A Walker, Rong Tian

Abstract readReview
In one paragraph

Review in Journal of molecular and cellular cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Effect of Nicotinamide Adenine Dinucleotide on Heart Failure Caused by Ischemic Cardiomyopathy: A Randomized, Placebo-Controlled Trial.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2026
    Trial
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. Biomarkers of Cardiac Metabolic Flexibility in Health, HFrEF and HFpEF.International journal of molecular sciences · 2026
    Review
  11. Review
  12. Article
  13. ATP-Citrate Lyase in Heart Failure: A Redox Node in NADJACC. Basic to translational science · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Matthew A WalkerMitochondria and Metabolism Center, Department of Anesthesiology & Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: mawalk1@uw.edu.
Rong TianMitochondria and Metabolism Center, Department of Anesthesiology & Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA. Electronic address: rongtian@uw.edu.

Funding

Diabetes, Obesity and Metabolism Training ProgramT32DK007247 · UNIVERSITY OF WASHINGTON · 1986 to 2025
$2.0M
UW Center for Translational Muscle ResearchP30AR074990 · UNIVERSITY OF WASHINGTON · 2025 to 2025
$789k
Mechanistic Studies of NAD+/NADH in Human Heart FailureR01HL144937 · NHLBI · UNIVERSITY OF WASHINGTON · PI Kevin D. O'Brien, Rong Tian · 2023 to 2023
$750k
American Heart Association-American Stroke Association 930223NHLBI NIH HHS R01 HL144937NHLBI NIH HHS R01 HL149695NIAMS NIH HHS P30 AR074990NIDDK NIH HHS T32 DK007247
6 · The paper itself

Abstract

Nicotinamide adenine dinucleotide provides the critical redox pair, NAD

Indexed as

Heart FailureNADAnimalsEnergy MetabolismHumansOxidation-ReductionOxidative StressSignal TransductionSirtuinsNADSirtuinsHeart failureMetabolismNAD(+)/NADHNicotinamide adenine dinucleotide

Identifiers

PMID39096536
PMCPMC11390314

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.