Evidence map›Paper›PMID 39097166›Full record

ReviewThe American journal of pathology2025

Spatial Transcriptomics: Integrating Morphology and Molecular Mechanisms of Kidney Diseases.

Pierre Isnard, Benjamin D Humphreys

Abstract readReview
In one paragraph

Review in The American journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Computer Vision Methods for Spatial Transcriptomics: A Survey.bioRxiv : the preprint server for biology · 2025
    Article
  9. Article
  10. Kidney deletions of Cyp27b1 fail to reduce serum 1,25(OH)The Journal of steroid biochemistry and molecular biology · 2025
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Pierre IsnardDivision of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri. Electronic address: pierre.isnard@inserm.fr.
Benjamin D HumphreysDivision of Nephrology, Department of Medicine, Washington University in St. Louis, St. Louis, Missouri; Department of Developmental Biology, Washington University in St. Louis, St. Louis, Missouri.

Funding

Washington University Chronic KidneyDisease National Resource CenterU54DK137332 · NIDDK · WASHINGTON UNIVERSITY · PI BENJAMIN D. HUMPHREYS · 2023 to 2026
$4.5M
Single-cell analysis to promote kidney repairUC2DK126024 · NIDDK · WASHINGTON UNIVERSITY · PI HUMPHREYS, BENJAMIN D., KIM, JUNHYONG · 2020 to 2024
$3.7M
NIDDK NIH HHS U54 DK137332NIDDK NIH HHS UC2 DK126024
6 · The paper itself

Abstract

The recent arrival of high-resolution spatial transcriptomics (ST) technologies is generating a veritable revolution in life sciences, enabling biomolecules to be measured in their native spatial context. By integrating morphology and molecular biology, ST technologies offer the potential of improving the understanding of tissue biology and disease and may also provide meaningful clinical insights. This review describes the main ST technologies currently available and the computational analysis for data interpretation and visualization, and illustrate their scientific and potential medical interest in the context of kidney disease. Finally, we discuss the perspectives and challenges of these booming new technologies.

Indexed as

Gene Expression ProfilingKidney DiseasesTranscriptomeAnimalsComputational BiologyHumansKidney

Identifiers

PMID39097166
PMCPMC12179522

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.