Evidence map›Paper›PMID 39098587›Full record

ArticleExperimental eye research2024

Aberrant lipid accumulation and retinal pigment epithelium dysfunction in PRCD-deficient mice.

Sree I Motipally, Douglas R Kolson, Tongju Guan, Saravanan Kolandaivelu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental eye research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Sree I MotipallyDepartment of Neuroscience, Rockefeller Neuroscience Institute, 33 Medical Centre Drive, West Virginia University, Morgantown, WV, 26506, USA; Department of Ophthalmology and Visual Sciences, One Medical Center Drive, ERMA 2nd Floor, West Virginia University, Morgantown, WV, 26505-9193, USA.
Douglas R KolsonDepartment of Ophthalmology and Visual Sciences, One Medical Center Drive, ERMA 2nd Floor, West Virginia University, Morgantown, WV, 26505-9193, USA.
Tongju GuanDepartment of Ophthalmology and Visual Sciences, One Medical Center Drive, ERMA 2nd Floor, West Virginia University, Morgantown, WV, 26505-9193, USA; Department of Biochemistry and Molecular Medicine, 64 Medical Center Drive, West Virginia University, Morgantown, WV, 26505-9193, USA.
Saravanan KolandaiveluDepartment of Ophthalmology and Visual Sciences, One Medical Center Drive, ERMA 2nd Floor, West Virginia University, Morgantown, WV, 26505-9193, USA; Department of Biochemistry and Molecular Medicine, 64 Medical Center Drive, West Virginia University, Morgantown, WV, 26505-9193, USA. Electronic address: kolandaivelus@hsc.wvu.edu.

Funding

WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
Mechanisms Behind Retinal Photoreceptor Cells Outer Segment BiogenesisR01EY028959 · NEI · WEST VIRGINIA UNIVERSITY · PI KOLANDAIVELU, SARAVANAN · 2018 to 2022
$1.9M
NEI NIH HHS R01 EY028959NIGMS NIH HHS P20 GM103434
6 · The paper itself

Abstract

Progressive Rod-Cone Degeneration (PRCD) is an integral membrane protein found in photoreceptor outer segment (OS) disc membranes and its function remains unknown. Mutations in Prcd are implicated in Retinitis pigmentosa (RP) in humans and multiple dog breeds. PRCD-deficient models exhibit decreased levels of cholesterol in the plasma. However, potential changes in the retinal cholesterol remain unexplored. In addition, impaired phagocytosis observed in these animal models points to potential deficits in the retinal pigment epithelium (RPE). Here, using a Prcd

Indexed as

Disease Models, AnimalRetinal Pigment EpitheliumTomography, Optical CoherenceAnimalsATP Binding Cassette Transporter 1Bruch MembraneCholesterolCholesterol EstersCone-Rod DystrophiesElectroretinographyImmunohistochemistryLipid MetabolismMacular DegenerationMiceMice, Inbred C57BLMice, KnockoutAbca1 protein, mouseATP Binding Cassette Transporter 1CholesterolCholesterol EstersCholesterolCholesterol estersDrusenLipid dropletsLipofuscinPhagocytosisPRCDRetinal degeneration

Identifiers

PMID39098587
PMCPMC11388538

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.