Evidence map›Paper›PMID 39098912›Full record

ArticleClinical rheumatology2024

Joint effect of rheumatoid arthritis and diet quality on cardiovascular and mortality outcomes: insights from the Women's Health Initiative.

Kanika Malani, Sushaili Pradhan, Mary Roberts, Nazmus Saquib, Linda Snetselaar, Aladdin Shadyab, Charles B Eaton

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Article in Clinical rheumatology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kanika MalaniWarren Alpert Medical School, Brown University, Providence, RI, USA. kanika_malani@brown.edu.ORCID http://orcid.org/0000-0002-9647-5064
Sushaili PradhanCenter for Primary Care and Prevention, Brown University, Pawtucket, RI, USA.
Mary RobertsCenter for Primary Care and Prevention, Brown University, Pawtucket, RI, USA.
Nazmus SaquibDepartment of Epidemiology, Sulaiman AlRajhi University, Al-Bukayriyah, Saudi Arabia.
Linda SnetselaarDepartment of Epidemiology, University of Iowa School of Public Health, Iowa City, IA, USA.
Aladdin ShadyabDepartment of Epidemiology, University of California Herbert Wertheim School of Public Health and Human Longevity Science, San Diego La Jolla, San Diego, CA, USA.
Charles B EatonCenter for Primary Care and Prevention, Brown University, Pawtucket, RI, USA.

Funding

Viral VectorP30CA086862 · NCI · UNIVERSITY OF IOWA · PI Michael J Goodheart · 2000 to 2026
$70.0M
6 · The paper itself

Abstract

objectivesThis study aimed to examine the combined impact of diet quality and rheumatoid arthritis (RA) on development of cardiovascular and mortality outcomes among postmenopausal women.

methodsA total of 99,840 women without baseline RA and 10,494 women with baseline RA were prospectively followed for an average of 12.7 years through the Women's Health Initiative. Diet quality was evaluated using food frequency questionnaires and the Healthy Eating Index 2015. Cardiovascular and mortality outcomes were identified through study follow-up. Four patient groups were used: Reference Group (no RA and healthy diet), Group 1 (no RA and unhealthy diet), Group 2 (RA and healthy diet), Group 3 (RA and unhealthy diet). Data was analyzed using multivariable Cox proportional regression models.

resultsAfter adjustment for confounders, Groups 1 and 3 developed significantly more cardiovascular disease (CVD), coronary heart disease, and incident stroke as compared to the reference. All groups developed more CVD-related mortality and all-cause mortality as compared to the reference. Among patients who already have RA, the incidence of these poorer cardiovascular outcomes does not significantly increase based on diet quality.

conclusionWhile healthy diet quality is associated with reduced adverse cardiovascular and mortality outcomes, RA overpowers the benefits that may be attained through a healthy diet, resulting in the fact that diet quality does not significantly change cardiovascular and mortality outcome incidence in those who already have RA. Conversely, in those who do not have RA, the benefits of a healthy diet are realized with significant reduction of adverse cardiovascular and mortality outcomes as compared to those with an unhealthy diet. Key Points •Healthy diet quality is associated with reduced adverse cardiovascular and mortality outcomes. •RA is associated with increased adverse cardiovascular and mortality outcomes. •While diet quality does not significantly change cardiovascular and mortality outcomes in those who already have RA, those without RA experience significant reduction of these adverse outcomes by adhering to a healthy diet.

Indexed as

Arthritis, RheumatoidCardiovascular DiseasesWomen's HealthAgedDietDiet, HealthyFemaleHumansIncidenceMiddle AgedPostmenopauseProportional Hazards ModelsProspective StudiesCardiovascular diseaseCoronary heart diseaseDietLifestyleMenopauseMortalityNutritionRheumatoid arthritisStrokeWomen

Identifiers

PMID39098912

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.