Evidence map›Paper›PMID 39099241›Full record

ArticleLab on a chip2024

Continuous flow delivery system for the perfusion of scaffold-based 3D cultures.

Zachary R Sitte, Elizabeth E Karlsson, Haolin Li, Haibo Zhou, Matthew R Lockett

Abstract read
In one paragraph

Article in Lab on a chip, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Zachary R SitteDepartment of Chemistry, University of North Carolina at Chapel Hill, 125 South Road, Chapel Hill, NC 27599-3290, USA. mlockett@unc.edu.ORCID 0000-0001-7445-4863
Elizabeth E KarlssonDepartment of Chemistry, University of North Carolina at Chapel Hill, 125 South Road, Chapel Hill, NC 27599-3290, USA. mlockett@unc.edu.
Haolin LiDepartment of Biostatistics, University of North Carolina at Chapel Hill, 135 Dauer Drive, Chapel Hill, NC 27599-7400, USA.
Haibo ZhouDepartment of Biostatistics, University of North Carolina at Chapel Hill, 135 Dauer Drive, Chapel Hill, NC 27599-7400, USA.
Matthew R LockettDepartment of Chemistry, University of North Carolina at Chapel Hill, 125 South Road, Chapel Hill, NC 27599-3290, USA. mlockett@unc.edu.ORCID 0000-0003-4851-7757

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Hazel B Nichols · 2001 to 2026
$36.3M
Biostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3M
Paper-based cultures supporting tissue-like structures for biochemical studies of oxygen gradients and screening applicationsR35GM128697 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Matthew Ryen Lockett · 2018 to 2026
$3.1M
Developing an in vitro to in vivo pipeline of mammary gland exposure-response relationships to per- and poly-fluoroalkyl substances (PFAS)R01ES032730 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LOCKETT, MATTHEW RYEN, OLDENBURG, AMY L · 2020 to 2024
$2.6M
NCI NIH HHS P30 CA016086NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES032730NIEHS NIH HHS T32 ES007018NIGMS NIH HHS R35 GM128697
6 · The paper itself

Abstract

The paper-based culture platform developed by Whitesides readily incorporates tissue-like structures into laboratories with established workflows that rely on monolayer cultures. Cell-laden hydrogels are deposited in these porous scaffolds with micropipettes; these scaffolds support the thin gel slabs, allowing them to be evaluated individually or stacked into thick constructs. The paper-based culture platform has inspired many basic and translational studies, each exploring how readily accessible materials can generate complex structures that mimic aspects of tissues

Indexed as

PerfusionTissue ScaffoldsCell Culture TechniquesCell Culture Techniques, Three DimensionalEquipment DesignHumansHydrogelsLab-On-A-Chip DevicesPrinting, Three-DimensionalHydrogels

Identifiers

PMID39099241
PMCPMC11391725

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.