Evidence map›Paper›PMID 39101028›Full record

ArticleBioactive materials2024

Oriented cellulose hydrogel: Directed tissue regeneration for reducing corneal leukoplakia and managing fungal corneal ulcers.

Lina Dong, Zixin Fan, Bixing Fang, Xiaoyu Zhao, Hongyi Yao, Gangpei Cai, Shuo Yang, Guoming Zhang, Xiaoqi Cheng, Yun Feng and 2 more

Abstract read
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. 3D Printing Strategies for Bioengineering Human Cornea.Advanced healthcare materials · 2026
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lina DongTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Zixin FanShenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, Guangdong, 518040, China.
Bixing FangDepartment of Otolaryngology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.
Xiaoyu ZhaoTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Hongyi YaoTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Gangpei CaiTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Shuo YangShenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, Guangdong, 518040, China.
Guoming ZhangShenzhen Eye Hospital, Jinan University, Shenzhen Eye Institute, Shenzhen, Guangdong, 518040, China.
Xiaoqi ChengTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Yun FengDepartment of Ophthalmology, Peking University Third Hospital, Beijing, 100191, China.
Shengli MiTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.
Wei SunTsinghua Shenzhen International Graduate School, Tsinghua University, Shenzhen, 518055, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fungal corneal ulcer is one of the leading causes of corneal blindness in developing countries. Corneal scars such as leukoplakia are formed due to inflammation, oxidative stress and non-directed repair, which seriously affect the patients' subsequent visual and life quality. In this study, drawing inspiration from the oriented structure of collagen fibers within the corneal stroma, we first proposed the directional arrangement of CuTA-CMHT hydrogel system at micro and macro scales based on the 3D printing extrusion method combined with secondary patterning. It played an antifungal role and induced oriented repair in therapy of fungal corneal ulcer. The results showed that it effectively inhibited

Indexed as

Cellulose hydrogelCorneal leukoplakiaFungal corneal ulcersNanozymeOriented tissue regeneration

Identifiers

PMID39101028
PMCPMC11292264

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.