Evidence map›Paper›PMID 39101823›Full record

ArticleMicrobiology spectrum2024

Effect of multifunctional cationic polymer coatings on mitigation of broad microbial pathogens.

Jianliang Gong, Chun-Yin Or, Eric Tung-Po Sze, Sidney Man-Ngai Chan, Pak-Long Wu, Peggy Miu-Yee Poon, Anthony K Y Law, Lucie Ulrychová, Jan Hodek, Jan Weber and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Jianliang GongC-POLAR Technologies Inc., West Vancouver, British Columbia, Canada.
Chun-Yin OrC-POLAR Technologies Inc., West Vancouver, British Columbia, Canada.
Eric Tung-Po SzeDepartment of Chemistry, The Chinese University of Hong Kong, Hong Kong, China.
Sidney Man-Ngai ChanSchool of Science and Technology, Hong Kong Metropolitan University, Hong Kong, China.
Pak-Long WuSchool of Science and Technology, Hong Kong Metropolitan University, Hong Kong, China.
Peggy Miu-Yee PoonSchool of Science and Technology, Hong Kong Metropolitan University, Hong Kong, China.
Anthony K Y LawDepartment of Mechanical Engineering, Hong Kong Polytechnic University, Hong Kong, China.
Lucie UlrychováInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czechia.
Jan HodekInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czechia.
Jan WeberInstitute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czechia.
Hui OuyangDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
My YangDepartment of Veterinary Population Medicine, University of Minnesota, Saint Paul, Minnesota, USA.
Stephanie M EiltsDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Montserrat TorremorellDepartment of Veterinary Population Medicine, University of Minnesota, Saint Paul, Minnesota, USA.
Yaakov KnoblochDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Christopher J HoganDepartment of Mechanical Engineering, University of Minnesota, Minneapolis, Minnesota, USA.
Christine AtallahDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.
Juliette DaviesSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.
John WinklerSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.
Ryan GordonSchool of Engineering, University of British Columbia, Kelowna, British Columbia, Canada.
Reza ZarghanishirazSchool of Engineering, University of British Columbia, Kelowna, British Columbia, Canada.
Mojtaba ZabihiSchool of Engineering, University of British Columbia, Kelowna, British Columbia, Canada.
Cole ChristiansonSchool of Engineering, University of British Columbia, Kelowna, British Columbia, Canada.
Deanne TaylorSchool of Nursing, University of British Columbia, Kelowna, British Columbia, Canada.
Alan RabinowitzRural Coordination Center of British Columbia, Vancouver, British Columbia, Canada.
Jared BaylisInterior Health Authority, Kelowna, British Columbia, Canada.
Joshua BrinkerhoffSchool of Engineering, University of British Columbia, Kelowna, British Columbia, Canada.
Jonathan P LittleSchool of Health and Exercise Sciences, University of British Columbia, Kelowna, British Columbia, Canada.
Ri LiSchool of Engineering, University of British Columbia, Kelowna, British Columbia, Canada.
Jeanne MoldenhauerC-POLAR Technologies, Inc., Las Vegas, Nevada, USA.
Michael K MansourDivision of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts, USA.ORCID 0000-0001-8892-8695

Funding

C-POLAR Technologies unrestricted grant
6 · The paper itself

Abstract

Infection control measures to prevent viral and bacterial infection spread are critical to maintaining a healthy environment. Pathogens such as viruses and pyogenic bacteria can cause infectious complications. Viruses such as SARS-CoV-2 are known to spread through the aerosol route and on fomite surfaces, lasting for a prolonged time in the environment. Developing technologies to mitigate the spread of pathogens through airborne routes and on surfaces is critical, especially for patients at high risk for infectious complications. Multifunctional coatings with a broad capacity to bind pathogens that result in inactivation can disrupt infectious spread through aerosol and inanimate surface spread. This study uses C-POLAR, a proprietary cationic, polyamine, organic polymer with a charged, dielectric property coated onto air filtration material and textiles. Using both SARS-CoV-2 live viral particles and bovine coronavirus models, C-POLAR-treated material shows a dramatic 2-log reduction in circulating viral inoculum. This reduction is consistent in a static room model, indicating simple airflow through a static C-POLAR hanging can capture significant airborne particles. Finally, Gram-positive and Gram-negative bacteria are applied to C-POLAR textiles using a viability indicator to demonstrate eradication on fomite surfaces. These data suggest that a cationic polymer surface can capture and eradicate human pathogens, potentially interrupting the infectious spread for a more resilient environment. IMPORTANCE: Infection control is critical for maintaining a healthy home, work, and hospital environment. We test a cationic polymer capable of capturing and eradicating viral and bacterial pathogens by applying the polymer to the air filtration material and textiles. The data suggest that the simple addition of cationic material can result in the improvement of an infectious resilient environment against viral and bacterial pathogens.

Indexed as

CationsCOVID-19PolymersSARS-CoV-2AerosolsAnimalsBacteriaCattleCoronavirus, BovineFomitesGram-Negative BacteriaHumansTextilesAerosolsCationsPolymerscationic polymerGram-negativeGram-positiveSARS-CoV-2

Identifiers

PMID39101823
PMCPMC11370243

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.