Evidence map›Paper›PMID 39102232›Full record

ArticleAnimal biotechnology2024

Genome-wide association studies for citric and lactic acids in dairy sheep milk in a New Zealand flock.

An Zongqi, Ana C Marshall, J M D R Jayawardana, Mike Weeks, Simon M Loveday, Warren McNabb, Nicolas Lopez-Villalobos

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In one paragraph

Article in Animal biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

An ZongqiSichuan Agricultural University, College of Science and Technology, Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Chengdu, P. R. China.
Ana C MarshallSchool of Agriculture and Environment, Massey University, Palmerston North, New Zealand.
J M D R JayawardanaSchool of Agriculture and Environment, Massey University, Palmerston North, New Zealand.
Mike WeeksSmart Foods & Bioproducts Group, AgResearch Ltd, Massey University, Palmerston North, New Zealand.
Simon M LovedayThe Riddet Institute, Massey University, Palmerston North, New Zealand.
Warren McNabbThe Riddet Institute, Massey University, Palmerston North, New Zealand.
Nicolas Lopez-VillalobosSchool of Agriculture and Environment, Massey University, Palmerston North, New Zealand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objectives of this study were to estimate genetic parameters for citric acid content (CA) and lactic acid content (LA) in sheep milk and to identify the associated candidate genes in a New Zealand dairy sheep flock. Records from 165 ewes were used. Heritability estimates based on pedigree records for CA and LA were 0.65 and 0.33, respectively. The genetic and phenotypic correlations between CA and LA were strong-moderate and negative. Estimates of genomic heritability for CA and LA were also high (0.85, 0.51) and the genomic correlation between CA and LA was strongly negative (-0.96 ± 0.11). No significant associations were found at the Bonferroni level. However, one intragenic SNP in C1QTNF1 (chromosome 11) was associated with CA, at the chromosomal significance threshold. Another SNP associated with CA was intergenic (chromosome 15). For LA, the most notable SNP was intragenic in CYTH1 (chromosome 11), the other two SNPs were intragenic in MGAT5B and TIMP2 (chromosome 11), and four SNPs were intergenic (chromosomes 1 and 24). The functions of candidate genes indicate that CA and LA could potentially be used as biomarkers for energy balance and clinical mastitis. Further research is recommended to validate the present results.

Indexed as

Citric AcidGenome-Wide Association StudyLactic AcidMilkPolymorphism, Single NucleotideAnimalsFemaleNew ZealandSheepCitric AcidLactic Acidcitric acidgenome-wide-association studylactic acidSheep milk

Identifiers

PMID39102232
PMCPMC12674232

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.