Evidence map›Paper›PMID 39103198›Full record

ArticleJournal of biophotonics2024

Texture-based speciation of otitis media-related bacterial biofilms from optical coherence tomography images using supervised classification.

Farzana R Zaki, Guillermo L Monroy, Jindou Shi, Kavya Sudhir, Stephen A Boppart

Abstract read
In one paragraph

Article in Journal of biophotonics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Artificial Intelligence in Label-Free Optical Imaging Applications.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Farzana R ZakiBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0003-0694-2464
Guillermo L MonroyBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0002-3669-8514
Jindou ShiBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0002-8906-1082
Kavya SudhirBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Stephen A BoppartBeckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0002-9386-5630

Funding

The Center for Label-free Imagingand Multiscale Biophotonics (CLIMB)P41EB031772 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Stephen A Boppart · 2022 to 2026
$7.6M
Otitis Media Diagnosis and TreatmentR01DC019412 · NIDCD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Stephen A Boppart, JOSEPH E KERSCHNER · 2022 to 2026
$2.6M
Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-Vivo Identification of Bacterial Otitis MediaR01EB028615 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOPPART, STEPHEN A, MAHADEVAN-JANSEN, ANITA · 2019 to 2022
$2.5M
Self-Locomotive Antimicrobial Micro-Robot (SLAM) Enhancing Biofilm-Infected Wound HealingR01AI160671 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KONG, HYUNJOON · 2022 to 2025
$1.7M
NIAID NIH HHS R01 AI160671NIBIB NIH HHS P41 EB031772NIBIB NIH HHS R01 EB028615NIDCD NIH HHS R01 DC019412NIH HHS P41EB031772NIH HHS R01AI160671NIH HHS R01DC019412NIH HHS R01EB028615
6 · The paper itself

Abstract

Otitis media (OM), a highly prevalent inflammatory middle-ear disease in children worldwide, is commonly caused by an infection, and can lead to antibiotic-resistant bacterial biofilms in recurrent/chronic OM cases. A biofilm related to OM typically contains one or multiple bacterial species. OCT has been used clinically to visualize the presence of bacterial biofilms in the middle ear. This study used OCT to compare microstructural image texture features from bacterial biofilms. The proposed method applied supervised machine-learning-based frameworks (SVM, random forest, and XGBoost) to classify multiple species bacterial biofilms from in vitro cultures and clinically-obtained in vivo images from human subjects. Our findings show that optimized SVM-RBF and XGBoost classifiers achieved more than 95% of AUC, detecting each biofilm class. These results demonstrate the potential for differentiating OM-causing bacterial biofilms through texture analysis of OCT images and a machine-learning framework, offering valuable insights for real-time in vivo characterization of ear infections.

Indexed as

BiofilmsOtitis MediaTomography, Optical CoherenceHumansImage Processing, Computer-AssistedSupervised Machine Learningbiofilmsgray‐level co‐occurrence matrixoptical coherence tomographyotitis mediaraincloud plotsrandom forestSHAPSVMtexture featureXGBoost

Identifiers

PMID39103198
PMCPMC11464188

What Socratic holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.