Evidence map›Paper›PMID 39103231›Full record

ArticleThe Journal of pharmacology and experimental therapeutics2024

Regulation of Cannabinoid and Opioid Receptor Levels by Endogenous and Pharmacological Chaperones.

Achla Gupta, Ivone Gomes, Aya Osman, Wakako Fujita, Lakshmi A Devi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pharmacology and experimental therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. GPCR Heterodimers: Implications for Biased Signaling.Handbook of experimental pharmacology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Achla GuptaDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Ivone GomesDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Aya OsmanDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Wakako FujitaDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.
Lakshmi A DeviDepartment of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, New York lakshmi.devi@mssm.edu.ORCID 0000-0002-2179-2874

Funding

Regulation Of Opioid Receptor Signaling by Endogenous PeptidesR01DA008863 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Lakshmi A Devi, Elyssa Margolis · 1995 to 2026
$6.1M
Post-translational Regulation of Opioid and Cannabinoid Receptors.R37DA008863 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DEVI, LAKSHMI A · 2012 to 2021
$4.6M
Enhancement of the endogenous opioid system by ketamineR01DA058681 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Lakshmi A Devi, LLOYD D FRICKER · 2023 to 2026
$2.3M
Post-translational regulation of opioid receptorsR56DA008863 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DEVI, LAKSHMI A · 2007 to 2007
$381k
Targeted Deorphanization of G Protein-Coupled ReceptorsR03TR002940 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI DEVI, LAKSHMI A · 2019 to 2019
$170k
NCATS NIH HHS R03 TR002940NIDA NIH HHS R01 DA008863NIDA NIH HHS R01 DA058681NIDA NIH HHS R37 DA008863NIDA NIH HHS R56 DA008863
6 · The paper itself

Abstract

Cannabinoid and opioid receptor activities can be modulated by a variety of post-translational mechanisms including the formation of interacting complexes. This study examines the involvement of endogenous and exogenous chaperones in modulating the abundance and activity of cannabinoid CB

Indexed as

Molecular ChaperonesAnimalsCannabidiolHEK293 CellsHumansMaleMiceMice, Inbred C57BLReceptor, Cannabinoid, CB1Receptors, CannabinoidReceptors, OpioidReceptors, Opioid, deltaRNA, MessengerSpinal CordCannabidiolMolecular ChaperonesReceptor, Cannabinoid, CB1Receptors, CannabinoidReceptors, OpioidReceptors, Opioid, deltaRNA, Messenger

Identifiers

PMID39103231
PMCPMC11493451

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.