Evidence mapPaperPMID 39103247Full record

ArticlePediatric obesity2024

An open-label 16-week study of liraglutide in adolescents with obesity post-sleeve gastrectomy.

Anna Zenno, Ejike E Nwosu, Syeda Z Fatima, Evan P Nadler, Nazrat M Mirza, Sheila M Brady, Sara A Turner, Shanna B Yang, Julia Lazareva, Jennifer A Te-Vasquez and 3 more

Abstract read
In one paragraph

Article in Pediatric obesity, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Assessment and medical management of weight regain after adolescent metabolic and bariatric surgery: a narrative review.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anna ZennoSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Ejike E NwosuSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Syeda Z FatimaSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Evan P NadlerChildren's National Hospital, Washington, DC, USA.
Nazrat M MirzaChildren's National Hospital, Washington, DC, USA.
Sheila M BradySection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Sara A TurnerNutrition Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Shanna B YangNutrition Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
Julia LazarevaSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Jennifer A Te-VasquezSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.
Kong Y ChenDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.
Stephanie T ChungDiabetes, Endocrinology, and Obesity Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0001-6989-0417
Jack A YanovskiSection on Growth and Obesity, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.ORCID https://orcid.org/0000-0001-8542-1637

Funding

Human Energy and Body Weight Regulation CoreZICDK071013 · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2025 to 2025
$1.8M
Physiology, Psychology, and Genetics of ObesityZIAHD000641 · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2025 to 2025
$1.6M
Pediatric Endocrinology Training ProgramZIEHD008944 · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · 2025 to 2025
$399k
Therapeutic targets in African-American youth with type 2 diabetesZIADK075133 · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · 2025 to 2025
$279k
Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health ZIAHD000641Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA DK075133Intramural NIH HHS ZIA HD000641Intramural NIH HHS ZIC DK071013Intramural NIH HHS ZIE HD008944National Institute of Diabetes and Digestive and Kidney Diseases, NIHNICHD Division of Intramural Research Early Career AwardOffice of Research on Women's Health (ORWH), NIH through the Bench-to-Bedside and Back Program 731903
6 · The paper itself

Abstract

backgroundUp to 50% of adolescents who undergo metabolic and bariatric surgery (MBS) have obesity 3 years post-MBS, placing them at continued risk for the consequences of obesity.

objectivesWe conducted an open-label, 16-week pilot study of liraglutide in adolescents with obesity after sleeve gastrectomy (SG) to investigate liraglutide effects on weight and body mass index (BMI) post-SG.

methodsAdolescents aged 12-20.99 years with obesity and a history of SG ≥1 year prior were enrolled. Liraglutide was initiated at 0.6 mg/day, escalated weekly to a maximum of 3 mg/day, with treatment duration 16 weeks. Fasting laboratory assessments and an oral glucose tolerance test were performed at baseline and end-treatment.

resultsA total of 43 participants were screened, 34 initiated liraglutide (baseline BMI 41.2 ± 7.7 kg/m

conclusionsLiraglutide treatment was feasible and associated with a BMI reduction of 4.3% in adolescents who had previously undergone SG, quantitatively similar to results obtained in adolescents with obesity who have not undergone MBS.

Indexed as

Body Mass IndexGastrectomyLiraglutidePediatric ObesityWeight LossAdolescentBariatric SurgeryBlood GlucoseChildFemaleGlycated HemoglobinHumansHypoglycemic AgentsMaleObesity, MorbidPilot ProjectsBlood GlucoseGlycated HemoglobinHypoglycemic AgentsLiraglutideadolescencebariatric surgeryGLP1obesitypharmacotherapyweight loss

Identifiers

PMID39103247
PMCPMC11486571

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.