ArticleMolecular psychiatry2025
Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2
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Article in Molecular psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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32citing papers in PubMed, 1 pooled it
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating the potential of acupuncture for Alzheimer's disease treatment: A meta-analysis and systematic review of mouse model studies.Translational psychiatry · 2026Pooled it
- Microglia and neuroinflammation: function, heterogeneity, and crosstalk.Cellular & molecular immunology · 2026Review
- Neurotransmitters in cancer: how receptor signaling and posttranslational modifications modulate tumor progression and offer new therapeutic targets.Cell communication and signaling : CCS · 2026Review
- Nmur1 and Cckar fail to support functional genetic access in adult dopamine neurons and challenge GPCR atlas assignments.bioRxiv : the preprint server for biology · 2026Article
- Genetic risk in Alzheimer's disease.NPJ systems biology and applications · 2026Review
- Atlas-Guided Nanocarrier Strategies Targeting Spatial NTRK2/MAPK Signaling in EGFR-TKI-Resistant Niches of Esophageal Squamous Cell Carcinoma.Pharmaceutics · 2026Review
- Imaging spatial transcriptomics reveals molecular patterns underlying accumulation of p-Ser129 α-synuclein in a transgenic mouse model.NPJ Parkinson's disease · 2026Article
- Spatial transcriptomics in Alzheimer's disease: technologies, challenges and discoveries.Molecular neurodegeneration advances · 2026Review
- Spatial omics of neuroinflammation: insights across brain diseases.Frontiers in immunology · 2026Review
- Trem2bioRxiv : the preprint server for biology · 2025Article
- MIMYR: Generative modeling of missing tissue in spatial transcriptomics.bioRxiv : the preprint server for biology · 2025Article
- Hippocampal neural circuit mechanisms in Alzheimer's disease revealed by viral-genetic circuit mapping.Neurobiology of disease · 2025Review
- Roles of TREM2 in Alzheimer's disease.Translational neurodegeneration · 2025Review
- Microglia networks within the tapestry of alzheimer's disease through spatial transcriptomics.Molecular neurodegeneration · 2025Review
- Super-Resolved Spatial Transcriptomics Reveals Early Changes in RNA Localization in the 5xFAD Hippocampus.bioRxiv : the preprint server for biology · 2025Article
- Isotope-encoded spatial biology identifies plaque-age-dependent maturation and synaptic loss in an Alzheimer's disease mouse model.Nature communications · 2025Article
- Precision Neuro-Oncology in Glioblastoma: AI-Guided CRISPR Editing and Real-Time Multi-Omics for Genomic Brain Surgery.International journal of molecular sciences · 2025Review
- Neural Circuit Mapping and Neurotherapy-Based Strategies.Cellular and molecular neurobiology · 2025Review
- Beyond the nuclear border: single-cell analysis of in situ sequenced human brain tissue using cellular features.Communications biology · 2025Article
- Unveiling blood biomarkers for neuronal hyperplasticity: Insights from AD molecular subtyping, a comprehensive review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
Corrections and comments
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Authors and funding
10 authors.
Kevin G JohnstonDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, 92697, USA.
Bereket T BerackeyDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, 92697, USA.
Kristine M TranDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, 92697, USA.
Alon GelberDepartment of Cognitive Science, University of California, San Diego, CA, 92037, USA.
Zhaoxia YuDepartment of Statistics, School of Computer and Information Science, University of California, Irvine, CA, 92697, USA.
Grant R MacGregorDepartment of Developmental and Cell Biology, University of California, Irvine, CA, 92697, USA.
Eran A MukamelDepartment of Cognitive Science, University of California, San Diego, CA, 92037, USA.ORCID 0000-0003-3203-9535
Zhiqun TanDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, 92697, USA.ORCID 0000-0002-2235-4577
Kim N GreenDepartment of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA, 92697, USA.ORCID 0000-0002-6049-6744
Xiangmin XuDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, 92697, USA. xiangmix@uci.edu.ORCID 0000-0002-5828-1533
Funding
UC Irvine MODEL-ADU54AG054349 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green · 2017 to 2026
$71.9MCell-type-specific neural circuit connectomes in the mouse models of aging and Alzheimer's diseaseU01AG076791 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Kim Green, ERAN A MUKAMEL · 2022 to 2026
$13.6MSingle-cell transcriptomic and epigenomic analysis of brain cell vulnerabilities to tauopathies in early AD impacted brain regionsR01AG082127 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MICHAEL D KOOB, Bing Ren · 2023 to 2026
$8.1MEpigenomic analysis of neural circuits in Alzheimer's disease mouse modelsR01AG067153 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI REN, BING, XU, XIANGMIN · 2020 to 2024
$3.8MNIDCD T32 Interdisciplinary Training Program in Hearing ResearchT32DC010775 · NIDCD · UNIVERSITY OF CALIFORNIA-IRVINE · PI Karina S Cramer, Raju Metherate · 2010 to 2026
$3.5MNeural circuit mechanisms underlying AD-related memory impairmentsRF1AG065675 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2020 to 2020
$1.9MNeural circuit mechanisms underlying AD-related memory impairmentsR01AG065675 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI XU, XIANGMIN · 2024 to 2024
$480kNIA NIH HHS R01 AG065675NIA NIH HHS R01 AG067153NIA NIH HHS R01 AG082127NIA NIH HHS RF1 AG065675NIA NIH HHS U01 AG076791NIA NIH HHS U54 AG054349NIDCD NIH HHS T32 DC010775U.S. Department of Health & Human Services | NIH | National Institute on Deafness and Other Communication Disorders (NIDCD) T32 DC010775-14
Abstract
The R47H missense mutation of the TREM2 gene is a known risk factor for development of Alzheimer's Disease. In this study, we analyze the impact of the Trem2
Indexed as
Alzheimer DiseaseMembrane GlycoproteinsReceptors, ImmunologicAnimalsAstrocytesBrainBrain-Derived Neurotrophic FactorDisease Models, AnimalGene Expression ProfilingHumansMaleMiceMice, TransgenicMicrogliaMutationMutation, MissenseBrain-Derived Neurotrophic FactorMembrane GlycoproteinsNtrk2 protein, mouseReceptors, ImmunologicReceptor, trkBTrem2 protein, mouse
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.