Evidence map›Paper›PMID 39104394›Full record

ArticleFrontiers in pharmacology2024

Synthesis, characterization, and mechanistic insights into the enhanced anti-inflammatory activity of baicalin butyl ester via the PI3K-AKT pathway.

Hongxu Du, Zhangxun Li, Lijuan Su, Zhengke He, Xiaoyan Tan, Fengzhi Hou, Tanjie He, Yu Pan, Shuang Xu, Liting Cao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hongxu DuDepartment of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing, China.
Zhangxun LiDepartment of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing, China.
Lijuan SuDepartment of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing, China.
Zhengke HeDepartment of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing, China.
Xiaoyan TanDepartment of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing, China.
Fengzhi HouDepartment of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing, China.
Tanjie HeDepartment of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing, China.
Yu PanDepartment of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing, China.
Shuang XuDepartment of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing, China.
Liting CaoDepartment of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing, China.
Shiqi DongDepartment of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing, China.
Yue MaDepartment of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Southwest University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the anti-inflammatory activity and mechanism of Baicalin derivative (Baicalin butyl ester, BE). Methods: BE was synthesized and identified using UV-Vis spectroscopy, FT-IR spectroscopy, mass spectrometry (MS) and high-performance liquid chromatography (HPLC) methods. Its anti-inflammatory potential was explored by an Results: UV-Vis, FT-IR, MS, and HPLC analyses confirmed the successfully synthesis of BE with a high purity of 93.75%. Conclusion: BE exhibits stronger anti-inflammatory activity relative to BA, possibly attributed to its better lipid solubility and cellular penetration capabilities. The anti-inflammatory mechanism of BE may be mediated through the PI3K-AKT pathway.

Indexed as

baicalin butyl esterinflammationmolecular dockingnetwork pharmacologytraditional Chinese medicine

Identifiers

PMID39104394
PMCPMC11298432

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.