Evidence map›Paper›PMID 39104914›Full record

ArticleIEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division2023

MRI-Conditional Eccentric-Tube Injection Needle: Design, Fabrication, and Animal Trial.

Anthony L Gunderman, Ehud J Schmidt, Qingyu Xiao, Junichi Tokuda, Ravi T Seethamraju, Luca Neri, Henry R Halperin, Carmen Kut, Akila N Viswanathan, Marc Morcos and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in IEEE/ASME transactions on mechatronics : a joint publication of the IEEE Industrial Electronics Society and the ASME Dynamic Systems and Control Division, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review of Robot-Assisted HIFU Therapy.Sensors (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Anthony L GundermanBiomedical Engineering Department, Georgia Institute of Technology/Emory University, Atlanta, GA, 30318 USA.
Ehud J SchmidtDepartment of Medicine, Johns Hopkins University, Baltimore, MD., 21205.
Qingyu XiaoBiomedical Engineering Department, Georgia Institute of Technology/Emory University, Atlanta, GA, 30318 USA.
Junichi TokudaDepartment of Radiology, Harvard Medical School, Boston, MA., 02115.
Ravi T SeethamrajuSiemens Healthineers Boston, Boston, MA, 02115.
Luca NeriDepartment of Medicine, Johns Hopkins University, Baltimore, MD., 21205.
Henry R HalperinDepartment of Medicine, Johns Hopkins University, Baltimore, MD., 21205.
Carmen KutDepartment of Radiation Oncology, Johns Hopkins University, Baltimore, MD., 21205.
Akila N ViswanathanDepartment of Radiation Oncology, Johns Hopkins University, Baltimore, MD., 21205.
Marc MorcosDepartment of Radiation Oncology, Johns Hopkins University, Baltimore, MD., 21205.
Yue ChenBiomedical Engineering Department, Georgia Institute of Technology/Emory University, Atlanta, GA, 30318 USA.

Funding

Improved Targeting and Assessment of Electrophysiology InterventionR01HL094610 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HALPERIN, HENRY R · 2009 to 2018
$15.5M
The Pathophysiology and Therapy of Pulseless Electrical ActivityR01HL126092 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HALPERIN, HENRY R · 2015 to 2018
$2.8M
Multiparametric Magnetic Resonance Imaging as a Novel Approach to Brachytherapy for Cervical CancerR01CA237005 · NCI · JOHNS HOPKINS UNIVERSITY · PI VISWANATHAN, AKILA · 2020 to 2024
$2.8M
MR Image Guided Gynecologic BrachytherapyR21CA167800 · NCI · JOHNS HOPKINS UNIVERSITY · PI VISWANATHAN, AKILA · 2013 to 2014
$394k
NCI NIH HHS R01 CA237005NCI NIH HHS R21 CA167800NHLBI NIH HHS R01 HL094610NHLBI NIH HHS R01 HL126092
6 · The paper itself

Abstract

Effective radiation therapy aims to maximize the radiation dose delivered to the tumor while minimizing damage to the surrounding healthy tissues, which can be a challenging task when the tissue-tumor space is small. To eliminate the damage to healthy tissue, it is now possible to inject biocompatible hydrogels between cancerous targets and surrounding tissues to create a spacer pocket. Conventional methods have limitations in poor target visualization and device tracking. In this paper, we leverage our MR-tracking technique to develop a novel injection needle for hydrogel spacer deployment. Herein, we present the working principle and fabrication method, followed by benchtop validation in an agar phantom, and MRI-guided validation in tissue-mimic prostate phantom and sexually mature female swine. Animal trials indicated that the spacer pockets in the rectovaginal septum can be accurately visualized on T2-weighted MRI. The experimental results showed that the vaginal-rectal spacing was successfully increased by 12 ± 2 mm anterior-posterior.

Indexed as

Active TrackingInjection NeedleMRI-ConditionalRadiation Therapy

Identifiers

PMID39104914
PMCPMC11299889

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.