Evidence map›Paper›PMID 39105243›Full record

ArticleProgress in transplantation (Aliso Viejo, Calif.)2024

Patient Perspectives on the Use of Aging Metrics for Kidney Transplant Decision-Making.

Akanksha Nalatwad, Evelien E Quint, Maria Fazal, Valerie Thompson, Xiaomeng Chen, Prakriti Shrestha, Sarah E Van Pilsum Rasmussen, Yiting Li, Dorry L Segev, Casey Jo Humbyrd and 1 more

Abstract read
In one paragraph

Article in Progress in transplantation (Aliso Viejo, Calif.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Akanksha NalatwadDepartment of Surgery, New York University Grossman School of Medicine and Langone Health, New York, New York, USA.
Evelien E QuintDivision of Transplant Surgery, Department of Surgery, University Medical Center Groningen, Groningen, The Netherlands.
Maria FazalDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Valerie ThompsonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Xiaomeng ChenDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Prakriti ShresthaDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sarah E Van Pilsum RasmussenDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Yiting LiDepartment of Surgery, New York University Grossman School of Medicine and Langone Health, New York, New York, USA.
Dorry L SegevDepartment of Surgery, New York University Grossman School of Medicine and Langone Health, New York, New York, USA.
Casey Jo HumbyrdDepartment of Orthopedic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Mara McAdams-DeMarcoDepartment of Surgery, New York University Grossman School of Medicine and Langone Health, New York, New York, USA.ORCID 0000-0003-3013-925X

Funding

Structural Racism, Resilience, and Premature Cognitive Aging in End-Stage Renal Disease - Revision - 5R01AG077888 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mara A. McAdams DeMarco · 2022 to 2026
$4.4M
Kidney transplantation in older, frail and cognitively impaired adults with ESRD: Balancing utility vs. justiceR01AG055781 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2017 to 2021
$4.2M
Hemodialysis-based interventions to preserve cognitive functionR01DK114074 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI MCADAMS DEMARCO, MARA A. · 2018 to 2022
$3.9M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Impact of climate change on cognitive and physical aging of older kidney transplant recipientsK02AG076883 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Mara A. McAdams DeMarco · 2023 to 2026
$728k
NIAID NIH HHS K24 AI144954NIA NIH HHS K02 AG076883NIA NIH HHS R01 AG055781NIA NIH HHS R01 AG077888NIDDK NIH HHS R01 DK114074
6 · The paper itself

Abstract

introductionFrailty and cognitive function are often measured during kidney transplant evaluation. However, patient perspectives on the ethical considerations of this practice are unclear. RESEARCH QUESTION: What are patient perspectives on the use of aging metrics in kidney transplant decision-making?

designOne hundred participants who were evaluated for kidney transplantation and were enrolled in an ongoing prospective cohort study (response rate = 61.3%) were surveyed. Participants were informed of the definitions of frailty and cognitive impairment and then asked survey questions regarding the use of these measures of aging to determine kidney transplant candidacy.

resultsParticipants (75.6%) thought it was unfair to prevent older adults from receiving a kidney transplant based on age, but there was less agreement on whether it was fair to deny frail (46.5%) and cognitively impaired (45.9%) patients from accessing kidney transplantation. Compared to older participants, younger participants had 5.36-times (95%CI:1.94-14.81) the odds of choosing a hypothetical younger, frail patient to list for kidney transplantation than an older, non-frail patient; they also had 3.56-times (95%CI:1.33-9.56) the odds of choosing the hypothetical frail patient with social support rather than a non-frail patient without social support. Participants disagreed on the use of patient age as a listing criterion; 19.5% ranked it as the fairest and 28.7% as the least fair.

conclusionThe patient views highlighted in this study are an important step toward developing ethical guidelines to ensure fair use of frailty, cognitive function, and chronological age for kidney transplant decision-making.

Indexed as

Decision MakingKidney TransplantationAdultAgedAge FactorsAgingFemaleFrailtyHumansMaleMiddle AgedProspective StudiesSurveys and Questionnairesagingbioethicscognitive impairmentfrailtyKidney transplant

Identifiers

PMID39105243
PMCPMC11449634

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.