Evidence map›Paper›PMID 39105654›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2024

Exercise improves load bearing bone structural properties in female secreted protein acidic and rich in cysteine (SPARC) null mice but not in males.

Giselle Kaneda, Dave Huang, Nathalie Pham, Alfonso R Gonzalez, Wafa Tawackoli, Seunghwan Lee, Miyako Suzuki, Trevor J Nelson, Juliane D Glaeser, Magali Millecamps and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giselle KanedaOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.ORCID 0000-0002-0547-9060
Dave HuangOrthopaedic Biomechanics Laboratory, CSMC, Los Angeles, California, USA.ORCID 0000-0003-0332-5823
Nathalie PhamOrthopaedic Biomechanics Laboratory, CSMC, Los Angeles, California, USA.
Alfonso R GonzalezOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.
Wafa TawackoliOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.ORCID 0000-0003-3742-8644
Seunghwan LeeThe Alan Edwards Centre for Research on Pain, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.
Miyako SuzukiThe Alan Edwards Centre for Research on Pain, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.ORCID 0000-0001-6427-3807
Trevor J NelsonOrthopaedic Biomechanics Laboratory, CSMC, Los Angeles, California, USA.
Juliane D GlaeserOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.
Magali MillecampsThe Alan Edwards Centre for Research on Pain, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.
Laura S StoneThe Alan Edwards Centre for Research on Pain, Faculty of Dentistry, McGill University, Montreal, Quebec, Canada.
Dmitriy SheynOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center (CSMC), Los Angeles, California, USA.ORCID 0000-0002-3333-1485
Melodie F MetzgerOrthopaedic Biomechanics Laboratory, CSMC, Los Angeles, California, USA.ORCID 0000-0001-8892-7035

Funding

Induced pluripotent stem cell therapy for degenerated IVDK01AR071512 · NIAMS · CEDARS-SINAI MEDICAL CENTER · PI SHEYN, DMITRIY · 2018 to 2022
$595k
CIHR MOP-142291Louise and Alan Edwards Foundation Catherine Bushnell Postdoctoral FellowshipNIAMS NIH HHS K01 AR071512NIH HHS K01AR071512
6 · The paper itself

Abstract

Secreted protein acidic and rich in cysteine (SPARC) is the most abundant glycoprotein in bone and is thought to play a critical role in bone remodeling and homeostasis. However, the effect of SPARC in relation to gender and exercise on bone quality is not well understood. The purpose of this study was to quantify differences in the structural and biomechanical properties between calvarial and femoral bone from male and female wild-type (WT) and SPARC null (SPARC

Indexed as

FemurMice, KnockoutOsteonectinPhysical Conditioning, AnimalSkullWeight-BearingAnimalsBiomechanical PhenomenaFemaleMaleMiceMice, Inbred C57BLSex CharacteristicsSex FactorsX-Ray MicrotomographyOsteonectinSPARC protein, mouseboneexsersiseosteonectinsex differencesSPARC

Identifiers

PMID39105654
PMCPMC12014150

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.