Evidence map›Paper›PMID 39107384›Full record

ArticleScientific reports2024

Potential anti-HIV and antitrypanosomal components revealed in Sorindeia nitidula via LC-ESI-QTOF-MS/MS.

Guy Roland Ebede, Emeka Emea Okoro, Josephine Ngo Mbing, Patrick Herve Diboue Betote, Dieudonne Emmanuel Pegnyemb, Muhammad Iqbal Choudhary, Xavier Siwe-Noundou, Joseph Thierry Ndongo

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Guy Roland EbedeDepartment of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
Emeka Emea OkoroDepartment of Biosciences, Nottingham Trent University, Clifton Campus, Nottingham, England.
Josephine Ngo MbingDepartment of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
Patrick Herve Diboue BetoteCentre for Research on Medicinal Plants and Traditional Medicine, Institute of Medical Research and Medicinal Plants Studies (IMPM), P.O Box 13033, Yaounde, Cameroon.
Dieudonne Emmanuel PegnyembDepartment of Organic Chemistry, Faculty of Science, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon.
Muhammad Iqbal ChoudharyH.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan.
Xavier Siwe-NoundouDepartment of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, P.O. Box 218, Pretoria, 0204, South Africa. xavier.siwenoundou@smu.ac.za.
Joseph Thierry NdongoDepartment of Chemistry, Higher Teacher Training College, University of Yaounde I, P.O. Box 47, Yaounde, Cameroon. joseph.ndongo@univ-yaounde1.cm.

Funding

Alexander von Humboldt-Stiftung 3.4-CMR/1155628Third World Academy of Sciences 3240299149
6 · The paper itself

Abstract

Sorindeia nitidula (Anacardiaceae) is used by traditional practitioners to treat influenza illnesses with cephalgia and febrile aches. However, the potential active ingredients for its remarkable antioxidant, anti-HIV and antitrypanosomal activities remain unexplored. The present study aims to evaluate the antioxidant, anti-HIV and antitrypanosomal activities of the ethyl acetate extract of S. nitidula (SN) in order to screen out the bioactive compounds and to analyze their possible mechanisms of action. Overall, 21 phenolic compounds were annotated, by using the MS and MS/MS information provided by the QTOF-MS. In vitro assays on the extract revealed potent antioxidant (IC

Indexed as

Anti-HIV AgentsPlant ExtractsTandem Mass SpectrometryAntioxidantsChromatography, LiquidHeLa CellsHumansSpectrometry, Mass, Electrospray IonizationTrypanocidal AgentsAnti-HIV AgentsAntioxidantsPlant ExtractsTrypanocidal Agents

Identifiers

PMID39107384
PMCPMC11303703

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.