Evidence map›Paper›PMID 39107753›Full record

ArticleBMC endocrine disorders2024

Serum ferritin level and associated factors among uncontrolled adult type II diabetic follow-up patients: comparative based cross-sectional study.

Andualem Bayih, Gobena Dedefo, Samuel Kinde, Mekdes Alem, Abebe Edao Negesso, Amanuel Baye, Abera Abreham, Abush Getaneh, Gizachew Taddesse Akalu, Alem Bayable and 4 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Andualem BayihDepartment of Medical Laboratory Science, College of Health Science, Dilla University, Dilla, Ethiopia. anbayih2009@gmail.com.
Gobena DedefoDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Samuel KindeDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Mekdes AlemDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Abebe Edao NegessoDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Amanuel BayeDepartment of Medical Laboratory Science, College of Health Science, Dilla University, Dilla, Ethiopia.
Abera AbrehamDepartment of Medical Laboratory Science, College of Health Science, Dilla University, Dilla, Ethiopia.
Abush GetanehDepartment of Medical Laboratory Science, College of Health Science, Dilla University, Dilla, Ethiopia.
Gizachew Taddesse AkaluDepartments of Microbiology, Immunology, and Parasitology, St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia.
Alem BayableDepartment of Adult Health Nursing, College of Medicine and Health Sciences, Dilla University, Dilla, Ethiopia.
Birku GashawDepartment of Medical Laboratory Science, College of Health Science, Wolkite University, Wolkite, Ethiopia.
Melaku TsegayeDepartment of Medical Laboratory Science, College of Health Science, Wolaita Sodo University, Wolaita, Ethiopia.
Geleta GemechuDepartment of Medical Laboratory Sciences, Rehoboth Harme College, Asella, Ethiopia.
Mistire WoldeDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUncontrolled type 2 diabetes mellitus (UT2DM) and its associated consequences nowadays have been a global health crisis, especially for adults. Iron has the property to oxidize and reduce reversibly, which is necessary for metabolic processes and excess accumulation of iron indicated by serum ferritin levels could have a significant impact on the pathophysiology of T2DM via generation of reactive oxygen species (ROS). However, no conclusive evidence existed about the association of serum ferritin with the state of glycemic control status. Therefore, this study aimed to evaluate serum ferritin levels and associated factors in uncontrolled T2DM patients and compare them with those of controlled T2DM and non-diabetic control groups.

methodsA hospital-based comparative cross-sectional study was conducted among conveniently selected 156 study participants, who were categorized into three equal groups of uncontrolled T2DM, controlled T2DM, and non-diabetic control groups from October 2 to December 29, 2023 at St. Paul's Hospital Millennium Medical College. A pre-tested structured questionnaire was used to collect socio-demographic and diabetes-related information. The laboratory tests were done using an automated chemistry analyzer and IBM-SPSS statistical software (version-27) was utilized for data entry and analysis with a significance level of p < 0.05.

resultThe mean serum ferritin level was noticeably higher in uncontrolled T2DM patients as compared to controlled T2DM and control groups (p < 0.001). It was significantly correlated with HbA1c [r = 0.457, p < 0.001], fasting blood sugar (FBs) [r = 0.386, p < 0.001], serum iron [r = 0.430, p < 0.001], and systolic blood pressure (SBP) [r = 0.195, p = 0.047] in T2DM patients. A multivariate logistic regression model revealed that a rise in HbA1c (AOR = 3.67, 95% CI(1.50-8.98), serum iron (AOR = 1.02, 95% CI(1.01-1.04), male gender (AOR = 0.16, 95% CI(0.05-0.57) and being on oral hypoglycemic agent (OHA) monotherapy (AOR = 0.26, 95% CI(0.07-0.95) were key associated factors for the elevated serum ferritin among T2DM patients.

conclusionThe present study demonstrated that T2DM patients had elevated serum ferritin levels which might be related to the existence of long-term hyperglycaemia and that serum ferritin had a significant positive association with HbA1c and FBs, implying that it could be used as an additional biomarker to predict uncontrolled T2DM patients.

Indexed as

Diabetes Mellitus, Type 2FerritinsAdultAgedBiomarkersBlood GlucoseCase-Control StudiesCross-Sectional StudiesFemaleFollow-Up StudiesGlycated HemoglobinHumansMaleMiddle AgedPrognosisBiomarkersBlood GlucoseFerritinsGlycated HemoglobinFerritinGlycemic controlHbA1cT2DM

Identifiers

PMID39107753
PMCPMC11305036

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.