Evidence map›Paper›PMID 39108362›Full record

ArticleJBMR plus2024

Bone turnover biomarkers reflect radiation-induced bone injuries in women with non-metastatic rectal cancer.

Per Magnusson, Maria Sääf, Anna Martling, Annika Svanström Röjvall, Diana Atanasova, Franciszek Wilamowski, Angelique Flöter Rådestad, Christian Buchli, Josefin Segelman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JBMR plus, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Per MagnussonDepartment of Clinical Chemistry, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SE-581 85, Sweden.ORCID https://orcid.org/0000-0002-2123-7838
Maria SääfDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, SE-171 77, Sweden.ORCID https://orcid.org/0000-0001-7004-3151
Anna MartlingDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, SE-171 77, Sweden.ORCID https://orcid.org/0000-0001-5998-4735
Annika Svanström RöjvallDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, SE-171 77, Sweden.ORCID https://orcid.org/0000-0003-1827-2744
Diana AtanasovaDepartment of Clinical Chemistry, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SE-581 85, Sweden.ORCID https://orcid.org/0000-0002-2688-3134
Franciszek WilamowskiDepartment of Radiology, Ersta Hospital, Stockholm, SE-116 91, Sweden.
Angelique Flöter RådestadDepartment of Hereditary Cancer, Karolinska University Hospital, Stockholm, SE-171 76, Sweden.ORCID https://orcid.org/0000-0002-1068-9732
Christian BuchliDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, SE-171 77, Sweden.ORCID https://orcid.org/0000-0003-4774-5395
Josefin SegelmanDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, SE-171 77, Sweden.ORCID https://orcid.org/0000-0002-7738-9806

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preoperative radiotherapy (RT) for non-metastatic rectal cancer reduces local recurrence rates but can cause pelvic insufficiency fractures. Despite the high morbidity from RT-induced skeletal injuries, predictive and preventive measures are lacking. How these injuries are reflected by bone biomarkers are largely unknown. The aim was to assess longitudinal changes in bone biomarkers and their relation to RT-related bone injuries in women with rectal cancer. This longitudinal cohort study includes 47 women with non-metastatic rectal cancer treated with surgery ± preoperative RT with or without chemotherapy. Sclerostin, bioactive sclerostin, C-terminal telopeptide cross-links of collagen type I (CTX), bone-specific alkaline phosphatase (BALP), and type I procollagen intact N-terminal propeptide (PINP) were measured at baseline, after RT, and 1 yr postoperatively. Pelvic magnetic resonance imaging was used for detection of skeletal injury. Sixteen of 36 (44%) irradiated women had radiation-induced bone injuries and were compared to 11 women (RT-) and 20 women (RT+) without bone injuries. Serum CTX, BALP, and PINP increased during the first year after RT in women with radiation-induced bone injuries. The difference in mean change of CTX (

Indexed as

bone injurybone-specific alkaline phosphatasebone turnover markersradiotherapysclerostin

Identifiers

PMID39108362
PMCPMC11299508

What Socratic holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.