Evidence map›Paper›PMID 39108503›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Quantitative PET imaging and modeling of molecular blood-brain barrier permeability.

Kevin J Chung, Yasser G Abdelhafez, Benjamin A Spencer, Terry Jones, Quyen Tran, Lorenzo Nardo, Moon S Chen, Souvik Sarkar, Valentina Medici, Victoria Lyo and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Kevin J ChungDepartment of Radiology, University of California Davis Health, Sacramento, CA.ORCID 0000-0003-4031-4365
Yasser G AbdelhafezDepartment of Radiology, University of California Davis Health, Sacramento, CA.
Benjamin A SpencerDepartment of Radiology, University of California Davis Health, Sacramento, CA.
Terry JonesDepartment of Radiology, University of California Davis Health, Sacramento, CA.
Quyen TranDepartment of Radiology, University of California Davis Health, Sacramento, CA.
Lorenzo NardoDepartment of Radiology, University of California Davis Health, Sacramento, CA.
Moon S ChenDepartment of Internal Medicine, University of California Davis Health, Sacramento, CA.
Souvik SarkarDepartment of Internal Medicine, University of California Davis Health, Sacramento, CA.
Valentina MediciDepartment of Internal Medicine, University of California Davis Health, Sacramento, CA.
Victoria LyoDepartment of Surgery, University of California Davis Health, Sacramento, CA.
Ramsey D BadawiDepartment of Radiology, University of California Davis Health, Sacramento, CA.
Simon R CherryDepartment of Biomedical Engineering, University of California at Davis, Davis, CA.
Guobao WangDepartment of Radiology, University of California Davis Health, Sacramento, CA.

Funding

Shared Resource ManagementP30CA093373 · UNIVERSITY OF CALIFORNIA DAVIS · 2002 to 2025
$10.6M
Single-tracer Multiparametric PET ImagingR01EB033435 · UNIVERSITY OF CALIFORNIA AT DAVIS · 2025 to 2025
$609k
Liver Parametric PETR01DK124803 · NIDDK · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Guobao Wang · 2023 to 2023
$524k
NCI NIH HHS P30 CA093373NCI NIH HHS R01 CA206187NIBIB NIH HHS R01 EB033435NIDDK NIH HHS R01 DK124803
6 · The paper itself

Abstract

Blood-brain barrier (BBB) disruption is involved in the pathogenesis and progression of many neurological and systemic diseases. Non-invasive assessment of BBB permeability in humans has mainly been performed with dynamic contrast-enhanced magnetic resonance imaging, evaluating the BBB as a structural barrier. Here, we developed a novel non-invasive positron emission tomography (PET) method in humans to measure the BBB permeability of molecular radiotracers that cross the BBB through different transport mechanisms. Our method uses high-temporal resolution dynamic imaging and kinetic modeling to jointly estimate cerebral blood flow and tracer-specific BBB transport rate from a single dynamic PET scan and measure the molecular permeability-surface area (PS) product of the radiotracer. We show our method can resolve BBB PS across three PET radiotracers with greatly differing permeabilities, measure reductions in BBB PS of

Identifiers

PMID39108503
PMCPMC11302722

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.