Evidence map›Paper›PMID 39108722›Full record

ArticleiScience2024

Heterozygous Gnaq deficiency enhances Ifi202b/IFI16 and NF-κB activation in endothelial cells and exacerbates lupus nephritis pathology.

Lu Zhang, Yan He, Mengqin Zhang, Jimin Zhang, Wuwei Zhuang, Yuechi Sun, Xing Chen, Hangzhou Fu, Xuanli Tang, Guixiu Shi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lu ZhangDepartment of Nephrology (Fujian Provincial Clinical Research Center for Glomerular Nephritis), The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Yan HeDepartment of Rheumatology and Clinical Immunology (Xiamen Municipal Clinical Research Center for Immune Diseases, Xiamen Key Laboratory of Rheumatology and Clinical Immunology), The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Mengqin ZhangDepartment of Rheumatology and Clinical Immunology (Xiamen Municipal Clinical Research Center for Immune Diseases, Xiamen Key Laboratory of Rheumatology and Clinical Immunology), The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Jimin ZhangDepartment of Rheumatology and Clinical Immunology (Xiamen Municipal Clinical Research Center for Immune Diseases, Xiamen Key Laboratory of Rheumatology and Clinical Immunology), The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Wuwei ZhuangDepartment of Rheumatology and Clinical Immunology (Xiamen Municipal Clinical Research Center for Immune Diseases, Xiamen Key Laboratory of Rheumatology and Clinical Immunology), The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Yuechi SunDepartment of Rheumatology and Clinical Immunology (Xiamen Municipal Clinical Research Center for Immune Diseases, Xiamen Key Laboratory of Rheumatology and Clinical Immunology), The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Xing ChenDepartment of Nephrology (Fujian Provincial Clinical Research Center for Glomerular Nephritis), The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Hangzhou FuDepartment of Pathology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Xuanli TangDepartment of Nephrology (Key Laboratory of Zhejiang Province, Management of Kidney Disease), Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, China.
Guixiu ShiDepartment of Rheumatology and Clinical Immunology (Xiamen Municipal Clinical Research Center for Immune Diseases, Xiamen Key Laboratory of Rheumatology and Clinical Immunology), The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), exhibits significant heterogeneity. Recent evidence suggests that non-immune factors contribute to end-organ damage, challenging the traditional view of LN solely arising from immune dysregulation. To investigate this, we employed autoimmune-prone

Indexed as

biological sciencesnatural sciencespathophysiologyphysiology

Identifiers

PMID39108722
PMCPMC11301098

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.